J M Van Deursen
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Explore the profile of J M Van Deursen including associated specialties, affiliations and a list of published articles.
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21
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2270
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Recent Articles
1.
Giotopoulos G, Chan W, Horton S, Ruau D, Gallipoli P, Fowler A, et al.
Oncogene
. 2015 Apr;
35(3):279-89.
PMID: 25893291
Growing evidence links abnormal epigenetic control to the development of hematological malignancies. Accordingly, inhibition of epigenetic regulators is emerging as a promising therapeutic strategy. The acetylation status of lysine residues...
2.
Naylor R, Baker D, Van Deursen J
Clin Pharmacol Ther
. 2012 Dec;
93(1):105-16.
PMID: 23212104
Aging is the main risk factor for most chronic diseases, disabilities, and declining health. It has been proposed that senescent cells--damaged cells that have lost the ability to divide--drive the...
3.
Baker D, Dawlaty M, Galardy P, Van Deursen J
Cell Mol Life Sci
. 2007 Mar;
64(5):589-600.
PMID: 17334950
Orderly progression through mitosis is regulated by the anaphase-promoting complex/cyclosome (APC/C), a large multiprotein E3 ubiquitin ligase that targets key mitotic regulators for destruction by the proteasome. APC/C has two...
4.
Jeganathan K, Van Deursen J
Biochem Soc Trans
. 2006 Jul;
34(Pt 4):583-6.
PMID: 16856867
Cdc20 (cell division cycle 20) and Cdh1 are the activating subunits of APC (anaphase-promoting complex), an E3-ubiquitin ligase that drives cells into anaphase by inducing degradation of cyclin B and...
5.
Kang-Decker N, Mantchev G, Juneja S, McNiven M, Van Deursen J
Science
. 2001 Nov;
294(5546):1531-3.
PMID: 11711676
The sperm acrosome is essential for sperm-egg fusion and is often defective in men with nonobstructive infertility. Here we report that male mice with a null mutation in Hrb are...
6.
von Bulow G, Van Deursen J, Bram R
Immunity
. 2001 May;
14(5):573-82.
PMID: 11371359
TACI is a TNFR homolog expressed by mature B lymphocytes that has been implicated in the positive regulation of B cell growth and antibody production, as well as in the...
7.
Wang X, Babu J, Harden J, Jablonski S, Gazi M, Lingle W, et al.
J Biol Chem
. 2001 May;
276(28):26559-67.
PMID: 11352911
The mRNA export factor RAE1 (also called GLE2) and the mitotic checkpoint protein BUB3 share extensive sequence homology in yeast as well as higher eukaryotes, although the biological relevance of...
8.
Wu X, Kasper L, Mantcheva R, Mantchev G, Springett M, Van Deursen J
Proc Natl Acad Sci U S A
. 2001 Mar;
98(6):3191-6.
PMID: 11248054
The NUP98 gene encodes precursor proteins that generate two nucleoplasmically oriented nucleoporins, NUP98 and NUP96. By using gene targeting, we have selectively disrupted the murine NUP98 protein, leaving intact the...
9.
Brown M, Nosaka T, Tripp R, Brooks J, Van Deursen J, Brenner M, et al.
Blood
. 1999 Sep;
94(6):1906-14.
PMID: 10477719
Expansion of early lymphoid progenitors requires interleukin-7 (IL-7), which functions through gamma(c)-mediated receptor activation of Jak3. Jak3 deficiency is a cause of severe combined immunodeficiency (SCID) in humans and mice....
10.
Pritchard C, Fornerod M, Kasper L, Van Deursen J
J Cell Biol
. 1999 Apr;
145(2):237-54.
PMID: 10209021
Gle2p is implicated in nuclear export of poly(A)+ RNA and nuclear pore complex (NPC) structure and distribution in Saccharomyces cerevisiae. Gle2p is anchored at the nuclear envelope (NE) via a...