J M Tavare
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Explore the profile of J M Tavare including associated specialties, affiliations and a list of published articles.
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66
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1160
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Recent Articles
1.
Vincent E, Elder D, Thomas E, Phillips L, Morgan C, Pawade J, et al.
Br J Cancer
. 2011 Apr;
104(11):1755-61.
PMID: 21505451
Background: The activity of the protein kinase Akt is frequently dysregulated in cancer and is an important factor in the growth and survival of tumour cells. Akt activation involves the...
2.
Lennon R, Welsh G, Singh A, Satchell S, Coward R, Tavare J, et al.
Diabetologia
. 2009 Jun;
52(9):1944-52.
PMID: 19533082
Aims/hypothesis: Peroxisome proliferator-activated receptor (PPAR) gamma agonists are used increasingly in the treatment of type 2 diabetes. In the context of renal disease, PPARgamma agonists reduce microalbuminuria in diabetic nephropathy;...
3.
Welsh G, Hers I, Wherlock M, Tavare J
Biochem Soc Trans
. 2006 Mar;
34(Pt 2):209-12.
PMID: 16545078
Several members of the extensive family of small GTP-binding proteins are regulated by insulin, and have been implicated in insulin action on glucose uptake. These proteins are themselves negatively regulated...
4.
Welsh G, Hers I, Berwick D, Dell G, Wherlock M, Birkin R, et al.
Biochem Soc Trans
. 2005 Mar;
33(Pt 2):346-9.
PMID: 15787603
The activation of protein kinase B (or Akt) plays a central role in the stimulation of glucose uptake by insulin. Currently, however, numerous questions remain unanswered regarding the role of...
5.
Ducluzeau P, Fletcher L, Vidal H, Laville M, Tavare J
Diabetes Metab
. 2002 Apr;
28(2):85-92.
PMID: 11976560
The stimulation of muscle and adipose tissue glucose metabolism, which is ultimately responsible for bringing about post-absorptive blood glucose clearance, is the primary clinically relevant action of insulin. Insulin acts...
6.
Tavare J, Fletcher L, Welsh G
J Endocrinol
. 2001 Aug;
170(2):297-306.
PMID: 11479127
Subcellular compartmentalisation of signalling molecules is an important phenomenon not only in defining how a signalling pathway is activated but also in influencing the desired physiological output of that pathway...
7.
Tavare J, Fletcher L, Oatey P, Tyas L, Wakefield J, Welsh G
Diabet Med
. 2001 Jul;
18(4):253-60.
PMID: 11437854
Understanding the mechanism of insulin action remains one of the most important challenges in modern medical biology. Recent advances in cell imaging techniques, increased processing power of computers and the...
8.
Tyas L, Brophy V, Pope A, Rivett A, Tavare J
EMBO Rep
. 2001 Mar;
1(3):266-70.
PMID: 11256610
Caspase-3 is a crucial component of the apoptotic machinery in many cell types. Here, we report the timescale of caspase-3 activation in single living cells undergoing apoptosis. This was achieved...
9.
10.
Fletcher L, Welsh G, Oatey P, Tavare J
Biochem J
. 2000 Nov;
352 Pt 2:267-76.
PMID: 11085918
Insulin stimulates glucose uptake into adipocytes by promoting the translocation of the glucose transporter isoform 4 (GLUT4) from intracellular vesicles to the plasma membrane. In 3T3-L1 adipocytes GLUT4 resides both...