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J L Croxford

Explore the profile of J L Croxford including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 458
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Recent Articles
1.
Olson J, Croxford J, Miller S
Viral Immunol . 2001 Sep; 14(3):227-50. PMID: 11572634
Virus infections have been implicated in the initiation of multiple human autoimmune diseases. This article focuses on reviewing the role of viruses in initiation, progression, and perpetuation of autoimmune diseases....
2.
Olson J, Croxford J, Calenoff M, Dal Canto M, Miller S
J Clin Invest . 2001 Jul; 108(2):311-8. PMID: 11457884
Molecular mimicry is the process by which virus infection activates T cells that are cross-reactive with self antigens. Infection of SJL/J mice with the neurotropic picornavirus Theiler's murine encephalomyelitis virus...
3.
Miller S, Olson J, Croxford J
J Autoimmun . 2001 May; 16(3):219-27. PMID: 11334486
Infection of SJL mice with wild-type BeAn strain of Theiler's murine encephalomyelitis virus (TMEV) leads to CD4(+)T cell-mediated CNS demyelination characterized by the development of anti-myelin epitope autoimmune responses via...
4.
Croxford J, Feldmann M, Chernajovsky Y, Baker D
J Immunol . 2001 Mar; 166(6):4124-30. PMID: 11238662
Experimental allergic encephalomyelitis (EAE) is a CNS autoimmune disease mediated by the action of CD4(+) T cells, macrophages, and proinflammatory cytokines. IL-10 is a cytokine shown to have many anti-inflammatory...
5.
Chernajovsky Y, Dreja H, Daly G, Annenkov A, Gould D, Adams G, et al.
Genes Immun . 2001 Feb; 1(5):295-307. PMID: 11196690
Animal models of autoimmune disease have been developed that mimic some aspects of the pathophysiology of human disease. These models have increased our understanding of possible mechanisms of pathogenesis at...
6.
Baker D, Pryce G, Croxford J, Brown P, Pertwee R, Makriyannis A, et al.
FASEB J . 2001 Feb; 15(2):300-2. PMID: 11156943
Spasticity is a complicating sign in multiple sclerosis that also develops in a model of chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice. In areas associated with nerve damage, increased...
7.
Baker D, Pryce G, Croxford J, Brown P, Pertwee R, Huffman J, et al.
Nature . 2000 Mar; 404(6773):84-7. PMID: 10716447
Chronic relapsing experimental allergic encephalomyelitis (CREAE) is an autoimmune model of multiple sclerosis. Although both these diseases are typified by relapsing-remitting paralytic episodes, after CREAE induction by sensitization to myelin...
8.
Croxford J, Triantaphyllopoulos K, Neve R, Feldmann M, Chernajovsky Y, Baker D
J Immunol . 2000 Feb; 164(5):2776-81. PMID: 10679120
In a murine relapsing experimental allergic encephalomyelitis (EAE) model, gene therapy to block TNF was investigated with the use of a retroviral dimeric p75 TNF receptor (dTNFR) construct. To effectively...
9.
Croxford J, ONeill J, Ali R, Browne K, Byrnes A, Dallman M, et al.
Eur J Immunol . 1998 Dec; 28(12):3904-16. PMID: 9862327
It has been reported previously that the induction phase of experimental allergic encephalomyelitis (EAE) is highly sensitive to systemic blockade of stimulation via MHC class II molecules and co-stimulation via...
10.
Croxford J, Triantaphyllopoulos K, Podhajcer O, Feldmann M, Baker D, Chernajovsky Y
J Immunol . 1998 May; 160(10):5181-7. PMID: 9590271
Experimental allergic encephalomyelitis (EAE) is an autoimmune disease of the central nervous system with many similarities to multiple sclerosis. The main effector cells involved are CD4+ T cells, recognizing encephalitogenic...