R G Pertwee
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Explore the profile of R G Pertwee including associated specialties, affiliations and a list of published articles.
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107
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8800
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Recent Articles
1.
Hill T, Cascio M, Romano B, Duncan M, Pertwee R, Williams C, et al.
Br J Pharmacol
. 2013 Aug;
170(3):679-92.
PMID: 23902406
Background And Purpose: Epilepsy is the most prevalent neurological disease and is characterized by recurrent seizures. Here, we investigate (i) the anticonvulsant profiles of cannabis-derived botanical drug substances (BDSs) rich...
2.
Bolognini D, Rock E, Cluny N, Cascio M, Limebeer C, Duncan M, et al.
Br J Pharmacol
. 2012 Nov;
168(6):1456-70.
PMID: 23121618
Background And Purpose: To evaluate the ability of cannabidiolic acid (CBDA) to reduce nausea and vomiting and enhance 5-HT(1A) receptor activation in animal models. Experimental Approach: We investigated the effect...
3.
Brown I, Wahle K, Cascio M, Smoum-Jaouni R, Mechoulam R, Pertwee R, et al.
Prostaglandins Leukot Essent Fatty Acids
. 2011 Oct;
85(6):305-10.
PMID: 21995886
Omega-3 (n-3) fatty acids inhibit breast and prostate cancer cell growth. We previously showed that N-acylethanolamine derivatives of n-3 (n-3-NAE) are endocannabinoids, which regulate cancer cell proliferation. These n-3-NAE are...
4.
Rock E, Bolognini D, Limebeer C, Cascio M, Anavi-Goffer S, Fletcher P, et al.
Br J Pharmacol
. 2011 Aug;
165(8):2620-34.
PMID: 21827451
Background And Purpose: To evaluate the hypothesis that activation of somatodendritic 5-HT(1A) autoreceptors in the dorsal raphe nucleus (DRN) produces the anti-emetic/anti-nausea effects of cannabidiol (CBD), a primary non-psychoactive cannabinoid...
5.
Pertwee R, Howlett A, Abood M, Alexander S, Di Marzo V, Elphick M, et al.
Pharmacol Rev
. 2010 Nov;
62(4):588-631.
PMID: 21079038
There are at least two types of cannabinoid receptors (CB(1) and CB(2)). Ligands activating these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ(9)-tetrahydrocannabinol, numerous synthetic compounds, and endogenous compounds known...
6.
Jamontt J, Molleman A, Pertwee R, Parsons M
Br J Pharmacol
. 2010 Jul;
160(3):712-23.
PMID: 20590574
Background And Purpose: Cannabis is taken as self-medication by patients with inflammatory bowel disease for symptomatic relief. Cannabinoid receptor agonists decrease inflammation in animal models of colitis, but their effects...
7.
Thors L, Burston J, Alter B, McKinney M, Cravatt B, Ross R, et al.
Br J Pharmacol
. 2010 Jul;
160(3):549-60.
PMID: 20590565
Background And Purpose: Inhibitors of fatty acid amide hydrolase (FAAH), the enzyme responsible for the metabolism of the endogenous cannabinoid (CB) receptor ligand anandamide (AEA), are effective in a number...
8.
Pertwee R
Addict Biol
. 2010 Jun;
5(1):37-46.
PMID: 20575818
Mammalian tissues contain at least two types of cannabinoid receptor, CB₁, found mainly on neurones and CB₂, found mainly in immune cells. Endogenous ligands for these receptors have also been...
9.
Pertwee R
Curr Med Chem
. 2010 Feb;
17(14):1360-81.
PMID: 20166927
It is widely accepted that non-endogenous compounds that target CB(1) and/or CB(2) receptors possess therapeutic potential for the clinical management of an ever growing number of disorders. Just a few...
10.
Cascio M, Gauson L, Stevenson L, Ross R, Pertwee R
Br J Pharmacol
. 2009 Dec;
159(1):129-41.
PMID: 20002104
Background And Purpose: Cannabis is the source of at least seventy phytocannabinoids. The pharmacology of most of these has been little investigated, three notable exceptions being Delta(9)-tetrahydrocannabinol, cannabidiol and Delta(9)-tetrahydrocannabivarin....