J L Christian
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Explore the profile of J L Christian including associated specialties, affiliations and a list of published articles.
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35
Citations
1704
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Recent Articles
1.
Fish L, Ewing M, Rich K, Xi C, Chen I, Jaime D, et al.
J Neurosci
. 2025 Jan;
PMID: 39880682
The neuromuscular junction (NMJ) is the linchpin of nerve-evoked muscle contraction. Broadly, the function of the NMJ is to transduce nerve action potentials into muscle fiber action potentials (MFAPs). Efficient...
2.
Cui Y, Hackenmiller R, Berg L, Jean F, Nakayama T, Thomas G, et al.
Genes Dev
. 2001 Nov;
15(21):2797-802.
PMID: 11691831
Proteolytic maturation of proBMP-4 is required to generate an active signaling molecule. We show that proBMP-4 is cleaved by furin in a sequential manner. Cleavage at a consensus furin site...
3.
Walters M, Wayman G, Christian J
Mech Dev
. 2001 Feb;
100(2):263-73.
PMID: 11165483
To examine potential roles for bone morphogenetic proteins (BMPs) in cardiogenesis, we used intracellular BMP inhibitors to disrupt this signaling cascade in Xenopus embryos. BMP-deficient embryos showed endodermal defects, a...
4.
Nakayama T, Berg L, Christian J
Mech Dev
. 2001 Feb;
100(2):251-62.
PMID: 11165482
Smad6 and Smad7 comprise a subclass of vertebrate Smads that antagonize, rather than transduce, TGF-beta family signaling. These Anti-Smads can block BMP signaling, as evidenced by their ability to induce...
5.
Wayman G, Walters M, Kolibaba K, Soderling T, Christian J
J Cell Biol
. 2000 Nov;
151(4):811-24.
PMID: 11076966
Developmental functions of calmodulin-dependent protein kinase IV (CaM KIV) have not been previously investigated. Here, we show that CaM KIV transcripts are widely distributed during embryogenesis and that strict regulation...
6.
Nakayama T, Cui Y, Christian J
Cell Mol Life Sci
. 2000 Aug;
57(6):943-56.
PMID: 10950309
Bone morphogenetic protein-4 (BMP-4) and its Drosophila ortholog, decapentaplegic (Dpp), are multifunctional developmental regulators. Both gain-of-function and loss-of-function studies demonstrate that the biological activity and signaling range of these morphogens...
7.
Christian J
Curr Opin Cell Biol
. 2000 May;
12(2):244-9.
PMID: 10819541
Wnt, Hedgehog and bone morphogenetic proteins function as either short-range or long-range signaling molecules depending on the tissue in which they are expressed. In the past year, filapodia-like cytoplasmic extensions,...
8.
Yoshitake Y, Howard T, Christian J, Hollenberg S
Dev Biol
. 1999 Nov;
215(2):375-87.
PMID: 10545244
In Drosophila, the Polycomb-group constitutes a set of structurally diverse proteins that act together to silence target genes. Many mammalian Polycomb-group proteins have also been identified and show functional similarities...
9.
Tian Q, Nakayama T, Dixon M, Christian J
Development
. 1999 Jul;
126(15):3371-80.
PMID: 10393116
The Xenopus Wnt-8 gene is transiently expressed in ventral and lateral mesoderm during gastrulation and plays a critical role in patterning these tissues. In the current study, we show that...
10.
Christian J, Nakayama T
Bioessays
. 1999 Jun;
21(5):382-90.
PMID: 10376010
The identification of Smad proteins as molecular components of the transforming growth factor-beta (TGF-beta) signaling cascade has enhanced our understanding of how ligand-mediated activation of TGF-beta receptors leads to modulation...