J L Bracy
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Explore the profile of J L Bracy including associated specialties, affiliations and a list of published articles.
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5
Citations
78
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Recent Articles
1.
Bracy J, Chase C, Russell P, Mauiyyedi S, Colvin R, Iacomini J
Gene Ther
. 2002 Mar;
8(22):1738-44.
PMID: 11892842
In order for xenotransplantation to become a clinical reality, and fulfill its promise of overcoming shortages of human organs and tissues, rejection mediated by the host's immune system must first...
2.
Bracy J, Cretin N, Cooper D, Iacomini J
Cell Mol Life Sci
. 2001 Feb;
56(11-12):1001-7.
PMID: 11212318
Shortages of human organs for transplantation have made it necessary to examine the possibility of using nonhuman organs for xenotransplantation the transplantation of tissues between different species. Pigs are now...
3.
Bracy J, Iacomini J
Blood
. 2000 Oct;
96(9):3008-15.
PMID: 11049978
The primary immunologic barrier to overcome before clinical xenotransplantation can be successful is rejection mediated by preformed natural antibodies in the host, directed toward a single carbohydrate epitope Galalpha1-3Galbeta1-4GlcNAc-R (alphaGal)...
4.
Bracy J, Sachs D, Iacomini J
Science
. 1998 Sep;
281(5384):1845-7.
PMID: 9743496
The major barrier to transplantation across discordant species, such as from pig to human, is rejection mediated by xenoreactive natural antibodies (XNA) that bind the carbohydrate epitope Galalpha1-3Galbeta1-4GlcNAc-R (alphaGal) on...
5.
Tolerization of anti-Galalpha1-3Gal natural antibody-forming B cells by induction of mixed chimerism
Yang Y, deGoma E, Ohdan H, Bracy J, Xu Y, Iacomini J, et al.
J Exp Med
. 1998 May;
187(8):1335-42.
PMID: 9547344
Xenotransplantation could overcome the severe shortage of allogeneic organs, a major factor limiting organ transplantation. Unfortunately, transplantation of organs from pigs, the most suitable potential donor species, results in hyperacute...