J Krijt
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Explore the profile of J Krijt including associated specialties, affiliations and a list of published articles.
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49
Citations
336
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Recent Articles
1.
Krijt J, Sokolova J, Silhavy J, Mlejnek P, Kubovciak J, Liska F, et al.
Physiol Res
. 2021 Sep;
70(5):687-700.
PMID: 34505526
Increased plasma total cysteine (tCys) has been associated with obesity and metabolic syndrome in human and some animal studies but the underlying mechanisms remain unclear. In this study, we aimed...
2.
Traeger L, Schnittker J, Dogan D, Oguama D, Kuhlmann T, Muckenthaler M, et al.
Free Radic Biol Med
. 2020 Aug;
160:501-505.
PMID: 32861780
Hepcidin deficiency leads to iron overload by increased dietary iron uptake and iron release from storage cells. The most frequent mutation in Hfe leads to reduced hepcidin expression and thereby...
3.
Silhavy J, Krijt J, Sokolova J, Zidek V, Mlejnek P, Simakova M, et al.
Physiol Res
. 2018 Aug;
67(4):657-662.
PMID: 30113208
Increased levels of plasma cysteine predispose to obesity and metabolic disturbances. Our recent genetic analyses in spontaneously hypertensive rats (SHR) revealed mutated Folr1 (folate receptor 1) on chromosome 1 as...
4.
Sebesta I, Stiburkova B, Krijt J
Nucleosides Nucleotides Nucleic Acids
. 2018 May;
37(6):324-328.
PMID: 29723117
Hereditary xanthinuria (type I) is caused by an inherited deficiency of the xanthine oxidorectase (XDH/XO), and is characterized by very low concentration of uric acid in blood and urine and...
5.
Fujikura Y, Krijt J, Povysil C, Melkova Z, Prikryl P, Vokurka M, et al.
Folia Biol (Praha)
. 2016 Aug;
62(3):95-102.
PMID: 27516188
Iron overload causes tissue damage in the liver, but its initial effects at the molecular and cellular level are not well understood. Epithelial cadherin (E-cad) is a major adhesion protein...
6.
Alcaide P, Krijt J, Ruiz-Sala P, Jesina P, Ugarte M, Kozich V, et al.
Clin Chim Acta
. 2014 Sep;
438:261-5.
PMID: 25218699
Background: Cystathionine β-synthase (CBS) is released into plasma from organs expressing this enzyme. Decreased plasma CBS activity has been demonstrated in CBS-deficient patients with 16 different genotypes. The aim of...
7.
Frydlova J, Fujikura Y, Vokurka M, Necas E, Krijt J
Physiol Res
. 2013 Apr;
62(4):405-11.
PMID: 23590607
Matriptase-2, a membrane protein encoded by the Tmprss6 gene, is a negative regulator of hepcidin expression. Although matriptase-2 has been proposed to cleave membrane hemojuvelin, we have recently found decreased...
8.
Szentivanyi K, Hansikova H, Krijt J, Vinsova K, Tesarova M, Rozsypalova E, et al.
Prague Med Rep
. 2012 Jun;
113(2):136-46.
PMID: 22691284
Tyrosine hydroxylase deficiency manifests mainly in early childhood and includes two clinical phenotypes: an infantile progressive hypokinetic-rigid syndrome with dystonia (type A) and a neonatal complex encephalopathy (type B). The...
9.
Vokurka M, Krijt J, Vavrova J, Necas E
Folia Biol (Praha)
. 2012 Jan;
57(6):248-54.
PMID: 22264719
Cancer is known to be an important cause of anaemia due to several factors including iron deficiency and inflammation. Hepcidin, a key regulator of iron metabolism, is up-regulated by iron...
10.
Zidkova L, Krijt J, Sladkova J, Hlobilkova A, Magner M, Zikanova M, et al.
Mol Genet Metab
. 2010 Aug;
101(2-3):286-8.
PMID: 20674424
Succinylpurines accumulate in the body fluids of patients with adenylosuccinate lyase (ADSL) deficiency but their source in the cerebrospinal fluid remains obscure. Study based on the incorporation of 13C-stable isotope-labeled...