E Necas
Overview
Explore the profile of E Necas including associated specialties, affiliations and a list of published articles.
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Articles
116
Citations
388
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0
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Recent Articles
1.
Necas E, Faltusova K, Chen C
Folia Biol (Praha)
. 2022 Feb;
67(4):135.
PMID: 35151237
No abstract available.
2.
Faltusova K, Bajecny M, Heizer T, Paral P, Necas E
Folia Biol (Praha)
. 2020 Aug;
66(2):47-59.
PMID: 32851834
Tagging cells of experimental organisms with genetic markers is commonly used in biomedical research. Insertion of artificial gene constructs can be highly beneficial for research as long as this tagging...
3.
Fujikura Y, Krijt J, Povysil C, Melkova Z, Prikryl P, Vokurka M, et al.
Folia Biol (Praha)
. 2016 Aug;
62(3):95-102.
PMID: 27516188
Iron overload causes tissue damage in the liver, but its initial effects at the molecular and cellular level are not well understood. Epithelial cadherin (E-cad) is a major adhesion protein...
4.
Frydlova J, Fujikura Y, Vokurka M, Necas E, Krijt J
Physiol Res
. 2013 Apr;
62(4):405-11.
PMID: 23590607
Matriptase-2, a membrane protein encoded by the Tmprss6 gene, is a negative regulator of hepcidin expression. Although matriptase-2 has been proposed to cleave membrane hemojuvelin, we have recently found decreased...
5.
Molinsky J, Klanova M, Maswabi B, Soukup T, Trneny M, Necas E, et al.
Folia Biol (Praha)
. 2013 Mar;
59(1):26-31.
PMID: 23537525
Mantle cell lymphoma (MCL) is an aggressive lymphoma subtype with dismal prognosis. New treatments are needed to improve outcome of relapsed/ refractory disease. Recently, several drugs targeting at least partially...
6.
Forgacova K, Necas E
Folia Biol (Praha)
. 2013 Mar;
59(1):1-14.
PMID: 23537523
Following transplantation, donor haematopoietic stem cells (HSCs) must reach specific parts of haematopoietic stroma tissue known as stem cell niches to become engrafted and to start blood cell production. Regularly,...
7.
Leahomschi S, Molinsky J, Klanova M, Andera L, Peterka M, Gasova Z, et al.
Neoplasma
. 2012 Dec;
60(2):223-31.
PMID: 23259793
Disruption of apoptotic pathways belongs to commonly reported molecular mechanisms that underlie cancer drug resistance. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL, Apo2L) is a cytokine of the TNF family...
8.
Curik N, Burda P, Vargova K, Pospisil V, Belickova M, Vlckova P, et al.
Leukemia
. 2012 Feb;
26(8):1804-11.
PMID: 22343522
Epigenetic 5-azacitidine (AZA) therapy of high-risk myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML) represents a promising, albeit not fully understood, approach. Hematopoietic transcription factor PU.1 is dynamically regulated by...
9.
Vokurka M, Krijt J, Vavrova J, Necas E
Folia Biol (Praha)
. 2012 Jan;
57(6):248-54.
PMID: 22264719
Cancer is known to be an important cause of anaemia due to several factors including iron deficiency and inflammation. Hepcidin, a key regulator of iron metabolism, is up-regulated by iron...
10.
Vokurka M, Lacinova Z, Kremen J, Kopecky P, Blaha J, Pelinkova K, et al.
Physiol Res
. 2009 Aug;
59(3):393-400.
PMID: 19681654
Hepcidin, a key regulator of iron metabolism, plays a crucial role in the pathogenesis of anemia of chronic disease. Although it is produced mainly in the liver, its recently described...