J J Jeffrey
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Explore the profile of J J Jeffrey including associated specialties, affiliations and a list of published articles.
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121
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1695
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Recent Articles
1.
Payne S, Maher M, Tran N, Van De Hey D, Foley T, Yueh A, et al.
Oncogenesis
. 2015 Oct;
4:e169.
PMID: 26436951
Aberrations in the phosphoinositide 3-kinase (PI3K) signaling pathway have a key role in the pathogenesis of numerous cancers by altering cell growth, metabolism, proliferation and apoptosis. Interest in targeting the...
2.
Holliday L, Welgus H, Hanna J, Lee B, Lu M, Jeffrey J, et al.
Calcif Tissue Int
. 2003 Jan;
72(3):206-14.
PMID: 12522662
Interstitial collagenase activity stimulates bone resorption by mouse marrow osteoclasts [1]. Here, we show that collagenase activity promotes bone resorption by activating adherent osteoclasts to resorb bone. Inhibition of interstitial...
3.
Ranganathan A, Nelson K, Rodriguez A, Kim K, Tower G, Rutter J, et al.
J Biol Chem
. 2001 Apr;
276(17):14264-70.
PMID: 11297530
Manganese-superoxide dismutase (Sod2) removes mitochondrially derived superoxide (O(2)) at near-diffusion limiting rates and is the only antioxidant enzyme whose expression is regulated by numerous stimuli. Here it is shown that...
4.
Melendez J, Vinci J, Jeffrey J, Wilcox B
Am J Physiol Regul Integr Comp Physiol
. 2001 Feb;
280(3):R879-88.
PMID: 11171669
Interleukin-1 (IL-1) has been implicated as a participant in preterm labor that is induced by bacterial infection. Previously, we showed that serotonin-induced production of IL-1alpha by myometrial smooth muscle cells...
5.
Wilcox C, Weisberg E, Dumin J, Wilcox B, Jeffrey J
Mol Cell Endocrinol
. 2001 Feb;
170(1-2):41-56.
PMID: 11162889
Primary cultures of uterine smooth muscle cells from post-partum rats express interstitial collagenase in response to serotonin and the serotonin-dependent production of interleukin-1 (IL-1) [Wilcox, B.D., Dumin, J.A. and Jeffrey,...
6.
Partridge N, Fiacco G, Walling H, Barmina O, Jeffrey J, Ruh M
Arch Biochem Biophys
. 2000 Nov;
382(2):182-8.
PMID: 11068867
Since estrogen is important in preventing osteoporosis in postmenopausal women and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an estrogen antagonist in reproductive tissues, we investigated the effects of 17beta-estradiol (E2) and TCDD on...
7.
Lan L, Vinci J, Melendez J, Jeffrey J, Wilcox B
Mol Cell Endocrinol
. 1999 Dec;
155(1-2):123-33.
PMID: 10580845
The regulation, by progesterone, of serotonin-induced interleukin-1alpha production was studied in primary cultures of rat uterine smooth muscle cells. Prior reports from this laboratory have demonstrated that these cells produce...
8.
Solis-Herruzo J, Rippe R, Schrum L, de la Torre P, Garcia I, Jeffrey J, et al.
J Biol Chem
. 1999 Oct;
274(43):30919-26.
PMID: 10521486
The role of IL-6 in collagen production and tissue remodeling is controversial. In Rat-1 fibroblasts, we measured the effect of IL-6 on matrix metalloproteinase-13 (MMP-13), c-jun, junB, and c-fos gene...
9.
Barmina O, Walling H, Fiacco G, Freije J, Lopez-Otin C, Jeffrey J, et al.
J Biol Chem
. 1999 Oct;
274(42):30087-93.
PMID: 10514495
We have previously identified a specific receptor for collagenase-3 that mediates the binding, internalization, and degradation of this ligand in UMR 106-01 rat osteoblastic osteosarcoma cells. In the present study,...
10.
Huang T, Vinci J, Lan L, Jeffrey J, Wilcox B
Mol Cell Endocrinol
. 1999 Aug;
152(1-2):21-35.
PMID: 10432220
Interleukin-1 has been shown to contribute to infection-induced inflammatory processes during pregnancy. Prior work from this laboratory has demonstrated that serotonin-induced IL-1alpha also is required for the in-vitro production of...