J Hurwitz
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Explore the profile of J Hurwitz including associated specialties, affiliations and a list of published articles.
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323
Citations
10688
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Recent Articles
1.
Tang D, Warholak T, Hines L, Hurwitz J, Brown M, Taylor A, et al.
Res Social Adm Pharm
. 2014 Feb;
10(5):768-80.
PMID: 24480384
Background: Comparative effectiveness research (CER) is a constellation of research methods designed to improve health care decision making. Educational programs that improve health care decision makers' CER knowledge and awareness...
2.
McCoy F, Hurwitz J, McTavish N, Paul I, Barnes C, OHagan B, et al.
Cell Death Dis
. 2011 Mar;
1:e108.
PMID: 21368880
Direct pharmacological targeting of the anti-apoptotic B-cell lymphoma-2 (BCL-2) family is an attractive therapeutic strategy for treating cancer. Obatoclax is a pan-BCL-2 family inhibitor currently in clinical development. Here we...
3.
Haracska L, Johnson R, Unk I, Phillips B, Hurwitz J, Prakash L, et al.
Proc Natl Acad Sci U S A
. 2001 Nov;
98(25):14256-61.
PMID: 11724965
Human DNA polymerase iota (hPoliota) promotes translesion synthesis by inserting nucleotides opposite highly distorting or noninstructional DNA lesions. Here, we provide evidence for the physical interaction of hPoliota with proliferating...
4.
Lee J, Moon K, Jiang Y, Hurwitz J
Proc Natl Acad Sci U S A
. 2001 Nov;
98(24):13589-94.
PMID: 11717425
The interaction between an origin sequence and the origin recognition complex (ORC), which is highly conserved in eukaryotes, is critical for the initiation of DNA replication. In this report, we...
5.
Haracska L, Johnson R, Unk I, Phillips B, Hurwitz J, Prakash L, et al.
Mol Cell Biol
. 2001 Oct;
21(21):7199-206.
PMID: 11585903
Human DNA polymerase eta (hPoleta) functions in the error-free replication of UV-damaged DNA, and mutations in hPoleta cause cancer-prone syndrome, the variant form of xeroderma pigmentosum. However, in spite of...
6.
Bermudez V, Hurwitz J, Sancar A
Proc Natl Acad Sci U S A
. 2001 Sep;
98(20):11236-41.
PMID: 11572977
Checkpoint Rad proteins function early in the DNA damage checkpoint signaling cascade to arrest cell cycle progression in response to DNA damage. This checkpoint ensures the transmission of an intact...
7.
DeAngelis D, Hurwitz J, Mazzulli T
Can J Ophthalmol
. 2001 May;
36(3):134-9.
PMID: 11367584
Background: In patients with nasolacrimal duct obstruction, the inflammation and fibrosis may be secondary to coexisting infectious colonization within the lumen of the lacrimal sac. We examined the bacterial flora...
8.
Lee J, Hurwitz J
Proc Natl Acad Sci U S A
. 2001 Jan;
98(1):54-9.
PMID: 11136247
The minichromosome maintenance (Mcm) proteins 2-7 are required for both the initiation and elongation steps of chromosomal DNA replication. Previous studies have shown that the Mcm complex consisting of the...
9.
Izumi M, Yanagi K, Mizuno T, Yokoi M, Kawasaki Y, Moon K, et al.
Nucleic Acids Res
. 2000 Nov;
28(23):4769-77.
PMID: 11095689
Mcm10 (Dna43), first identified in Saccharomyces cerevisiae, is an essential protein which functions in the initiation of DNA synthesis. Mcm10 is a nuclear protein that is localized to replication origins...
10.
Wang M, Park J, Ishiai M, Hurwitz J, Lee S
Nucleic Acids Res
. 2000 Nov;
28(23):4742-9.
PMID: 11095685
Replication protein A (RPA) is a three-subunit protein complex with multiple functions in DNA replication. Previous study indicated that human RPA (h-RPA) could not be replaced by Schizosaccharomyces pombe RPA...