J H Widdicombe
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Explore the profile of J H Widdicombe including associated specialties, affiliations and a list of published articles.
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Articles
117
Citations
2334
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Recent Articles
1.
Widdicombe J, Borthwell R, Hajighasemi-Ossareh M, Lachowicz-Scroggins M, Finkbeiner W, Stevens J, et al.
Am J Physiol Lung Cell Mol Physiol
. 2012 Feb;
302(10):L1098-106.
PMID: 22367783
Malfunction of airway submucosal glands contributes to the pathology of cystic fibrosis (CF), and cell cultures of CF human airway glands show defects in Cl(-) and water transport. Recently, a...
2.
Rajagopal M, Fischer H, Widdicombe J
Am J Physiol Endocrinol Metab
. 2008 Apr;
295(1):E55-62.
PMID: 18430967
Because an increase in the HCO(3)(-) concentration of oviductal liquid at midcycle is believed to markedly enhance fertility, we have studied active secretion of HCO(3)(-) across highly differentiated cultures of...
3.
Rajagopal M, Tollner T, Finkbeiner W, Cherr G, Widdicombe J
In Vitro Cell Dev Biol Anim
. 2006 Dec;
42(8-9):248-54.
PMID: 17163779
We have established well-differentiated, polarized cultures of monkey oviductal epithelium. Oviductal epithelial cells were isolated by protease digestion and plated on collagen-coated, porous cell culture inserts. About 5 d after...
4.
Dubin R, Robinson S, Widdicombe J
Am J Physiol Lung Cell Mol Physiol
. 2004 Mar;
286(4):L750-5.
PMID: 15003937
Lactoferrin and lysozyme are important antimicrobial compounds of airway surface liquid, derived predominantly from serous cells of submucosal glands but also from surface epithelium. Here we compared release of these...
5.
Lopez-Souza N, Dolganov G, Dubin R, Sachs L, Sassina L, Sporer H, et al.
Am J Physiol Lung Cell Mol Physiol
. 2004 Jan;
286(2):L373-81.
PMID: 14711802
Virtually all in vitro studies of the effects of rhinovirus on human airway epithelium have used cells grown under conditions known to produce low levels of differentiation. The relevance of...
6.
Sachs L, Finkbeiner W, Widdicombe J
In Vitro Cell Dev Biol Anim
. 2003 Aug;
39(1-2):56-62.
PMID: 12892528
The purpose of the this study was to find media that supported high levels of differentiation in primary cultures of human tracheal epithelium. We tested six previously described, partially defined...
7.
Widdicombe J, Sachs L, Finkbeiner W
In Vitro Cell Dev Biol Anim
. 2003 Aug;
39(1-2):51-5.
PMID: 12892527
Optical measurements from epithelial cells grown on clear solid surfaces (e.g., coverslips, petri dishes) are often compared with other measurements (e.g., short-circuit current; I(sc)) obtained from cells grown on opaque...
8.
Widdicombe J
J Anat
. 2002 Nov;
201(4):313-8.
PMID: 12430955
The airways are lined with a film of liquid about 10 microm deep that is in two layers. Around the cilia is the watery periciliary sol. Over this is a...
9.
Widdicombe J, Pecson I
Equine Vet J
. 2002 Oct;
34(6):630-3.
PMID: 12358006
Horses commonly suffer from respiratory diseases associated with excess secretions in the airway lumen, some of which are presumably derived from airway mucous glands. However, these structures have been little...
10.
Serikov V, Jang Y, Widdicombe J
J Appl Physiol (1985)
. 2002 Mar;
92(4):1702-8.
PMID: 11896040
Inflammatory diseases of the upper respiratory tract are characterized by flow of plasma filtrate across the epithelium into the airway lumen ("transudation"). Elsewhere, we have proposed that extravasation from microvessels...