J H Poupaert
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Explore the profile of J H Poupaert including associated specialties, affiliations and a list of published articles.
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Recent Articles
21.
Scriba G, Lambert D, Poupaert J
J Pharm Pharmacol
. 1995 Nov;
47(11):945-8.
PMID: 8708990
The bioavailability of phenytoin was evaluated in rats upon oral administration of phenytoin-lipid conjugates obtained by covalent binding of 3-hydroxymethylphenytoin to 1,3-dimyristoylglyceride via a succinidyl linkage, to 2-(1,3-dimyristoyl-2-glyceryl)butyric acid and...
22.
Bailleux V, Vallee L, NUYTS J, Hamoir G, Poupaert J, Stables J, et al.
Epilepsia
. 1995 Jun;
36(6):559-65.
PMID: 7555967
We compared the anticonvulsant activity and neurotoxicity of 4-amino-N-(2,6-dimethylphenyl)phthalimide (ADD 213063) with those of phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), ethosuximide (ESM), valproate (VPA), and felbamate (FBM). Evaluation of anticonvulsant...
23.
Lambert D, Geurts M, Scriba G, Poupaert J, Dumont P
J Pharm Belg
. 1995 Mar;
50(2-3):194-203.
PMID: 7674119
With GABA, glycine and beta-alanine are inhibitory amino acids. They act mainly in the spinal cord and in the brain stem via the strychnine sensitive glycine receptor. Glycine exhibits also...
24.
Scriba G, Lambert D, Poupaert J
J Pharm Sci
. 1995 Mar;
84(3):300-2.
PMID: 7616367
The plasma levels of phenytoin after oral administration of phenytoin and phenytoin 2-monoglyceride, a phenytoin prodrug, to rats were determined by gas chromatography. Compared to the application of the parent...
25.
Mbela T, Poupaert J, Cumps J, Moussebois C, Haemers A, Borloo M, et al.
J Pharm Pharmacol
. 1995 Mar;
47(3):237-42.
PMID: 7602488
Phenyl-substituted normethadone derivatives were synthesized and their affinity (IC50) for opioid receptors was determined by displacement of the specific binding sites of [3H]sufentanyl on rat brain preparations. Substitution resulted in...
26.
Scriba G, Lambert D, Poupaert J
J Pharm Pharmacol
. 1995 Mar;
47(3):197-203.
PMID: 7602480
The anticonvulsant activity of phenytoin-lipid conjugates obtained by covalent binding of 3-hydroxy-methylphenytoin to dimyristoylglycerides via a succinidyl linkage, to 2-(1,3-dimyristoylglyceryl)butyric acid and to 3-myristoyl-2-myristoylmethylpropionic acid was evaluated in the maximal...
27.
Lambert D, Mergen F, Berens C, Poupaert J, Dumont P
Pharm Res
. 1995 Feb;
12(2):187-91.
PMID: 7784331
The design of 1,3-dacylaminopropan-2-ols as CNS-directed carrier groups is based on their resemblance to endogenous lipids and the properties of pseudotriglyceride esters to facilitate the brain penetration of therapeutic agents....
28.
Lambert D, Poupaert J, Maloteaux J, Dumont P
Neuroreport
. 1994 Mar;
5(7):777-80.
PMID: 8018849
Although glycine does not cross easily the blood-brain barrier, it exhibits at very high doses (10-40 mmol kg-1) a modest anticonvulsant activity. In this study, carbamate derivatives--N-benzyloxycarbonylglycine (Z-glycine) and N,tert-butoxycarbonylglycine...
29.
Lambert D, Mergen F, Poupaert J, Dumont P
Eur J Pharmacol
. 1993 Oct;
243(2):129-34.
PMID: 8276061
As hydrolysis in serum of acetorphan to acetylthiorphan (N-[(R,S)-3-acetylmercapto-2-benzylpropanoyl]glycine) has been evidenced, both the neutral endopeptidase inhibition in vitro by acetylthiorphan and analgesic potency of acetylthiorphan after intravenous administration to...
30.
Tinant B, Declerq J, Poupaert J, Lesieur D
J Pharm Belg
. 1993 May;
48(3):208-10.
PMID: 8410625
No abstract available.