J H Hochman
Overview
Explore the profile of J H Hochman including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
17
Citations
311
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Yamazaki M, Li B, Louie S, Pudvah N, Stocco R, Wong W, et al.
Xenobiotica
. 2005 Dec;
35(7):737-53.
PMID: 16316932
The effects of different fibric acid derivatives (bezafibrate, clofibrate, clofibric acid, fenofibrate, fenofibric acid and gemfibrozil) on human organic anion transporting-polypeptide 1B1 (OATP2, OATP-C, SLC21A6), multidrug resistance protein 2 (MRP2/ABCC2)...
2.
Prueksaritanont T, Hochman J, Meng Y, Pudvah N, Barrish A, Ma B, et al.
Xenobiotica
. 2005 Apr;
34(11-12):1059-74.
PMID: 15801548
Compound A (3-{2-oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]napthyridin-2-yl)propyl]-imidazolidin-1-yl}-3(S)-(6-methoxy-pyridin-3-yl)propionic acid), a hydrophilic zwitter-ion, is a potent and selective alphavbeta3 integrin antagonist currently under clinical development for the treatment of osteoporosis. The mechanism of renal excretion of...
3.
Hochman J, Chiba M, Yamazaki M, Tang C, Lin J
J Pharmacol Exp Ther
. 2001 Jun;
298(1):323-30.
PMID: 11408558
The role of P-glycoprotein in secretion of indinavir metabolites produced by CYP3A4 was evaluated in Caco-2 cells expressing CYP3A4. Metabolism of indinavir by CYP3A4 expressing Caco-2 cells grown on filters...
4.
Yamazaki M, Neway W, Ohe T, Chen I, Rowe J, Hochman J, et al.
J Pharmacol Exp Ther
. 2001 Feb;
296(3):723-35.
PMID: 11181899
Two different cellular assay models were assessed as in vitro systems for P-glycoprotein (P-gp) substrate identification: cellular accumulation studies with KB-V1, a human MDR1 P-gp-overexpressing multidrug-resistant human epidermoid carcinoma cell...
5.
Tang C, Chiba M, Nishime J, Hochman J, Chen I, Williams T, et al.
Drug Metab Dispos
. 2000 May;
28(6):680-6.
PMID: 10820141
Methylation at the 2-position of the imidazole ring of IBN (I), a 1, 5-substituted imidazole-containing compound, was carried out to minimize its inhibition of rat cytochrome P450 (CYP)3A activity. The...
6.
LeCluyse E, Fix J, Audus K, Hochman J
Toxicol In Vitro
. 2000 May;
14(2):117-32.
PMID: 10793290
The morphological and cytoskeletal reorganization of collagen-sandwiched rat hepatocytes during the de novo formation of complete canalicular networks was examined by phase, fluorescence and electron microscopy. During the initial stages...
7.
Hochman J, Chiba M, Nishime J, Yamazaki M, Lin J
J Pharmacol Exp Ther
. 1999 Dec;
292(1):310-8.
PMID: 10604964
Caco-2 cells grown in the presence of 1alpha,25-di-OH vitamin D(3) (di-OH vit D(3)) were used as a model to evaluate the effects of P-glycoprotein (Pgp) efflux on CYP3A4-mediated metabolism of...
8.
Prueksaritanont T, Gorham L, Ellis J, Fernandez-Metzler C, Deluna P, Gehret J, et al.
Drug Metab Dispos
. 1996 Nov;
24(11):1263-71.
PMID: 8937862
The pharmacokinetics and bioavailability of L-751,164, an ethyl ester prodrug of a potent fibrinogen receptor antagonist, L-742,998, were studied in beagle dogs and rhesus monkeys. In both species, L-751,164 exhibited...
9.
Prueksaritanont T, Gorham L, Hochman J, Tran L, Vyas K
Drug Metab Dispos
. 1996 Jun;
24(6):634-42.
PMID: 8781778
Drug-metabolizing enzymes were studied in subcellular fractions of dog, monkey, and human small intestines, and in the human adenocarcinoma cell line Caco-2, a commonly used in vitro absorption model. Immunoblot...
10.
LeCluyse E, Bullock P, Parkinson A, Hochman J
Pharm Biotechnol
. 1996 Jan;
8:121-59.
PMID: 8791809
No abstract available.