J G Conboy
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Explore the profile of J G Conboy including associated specialties, affiliations and a list of published articles.
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34
Citations
1035
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Recent Articles
1.
Purdom E, Simpson K, Robinson M, Conboy J, Lapuk A, Speed T
Bioinformatics
. 2008 Jun;
24(15):1707-14.
PMID: 18573797
Motivation: Analyses of EST data show that alternative splicing is much more widespread than once thought. The advent of exon and tiling microarrays means that researchers now have the capacity...
2.
Brudno M, Gelfand M, Spengler S, Zorn M, Dubchak I, Conboy J
Nucleic Acids Res
. 2001 May;
29(11):2338-48.
PMID: 11376152
Alternative pre-mRNA splicing is a major cellular process by which functionally diverse proteins can be generated from the primary transcript of a single gene, often in tissue-specific patterns. The current...
3.
Hou V, Conboy J
Curr Opin Hematol
. 2001 Feb;
8(2):74-9.
PMID: 11224680
Although the mature enucleated erythrocyte is no longer active in nuclear processes such as pre-mRNA splicing, the function of many of its major structural proteins is dependent on alternative splicing...
4.
Nunomura W, Takakuwa Y, Parra M, Conboy J, Mohandas N
J Biol Chem
. 2000 Feb;
275(9):6360-7.
PMID: 10692436
In vitro protein binding assays identified two distinct calmodulin (CaM) binding sites within the NH(2)-terminal 30-kDa domain of erythrocyte protein 4.1 (4.1R): a Ca(2+)-independent binding site (A(264)KKLWKVCVEHHTFFRL) and a Ca(2+)-dependent...
5.
Parra M, Gascard P, Walensky L, Gimm J, Blackshaw S, Chan N, et al.
J Biol Chem
. 2000 Feb;
275(5):3247-55.
PMID: 10652311
Brain-enriched isoforms of skeletal proteins in the spectrin and ankyrin gene families have been described. Here we characterize protein 4.1B, a novel homolog of erythrocyte protein 4.1R that is encoded...
6.
Gee S, Aoyagi K, Lersch R, Hou V, Wu M, Conboy J
Blood
. 2000 Jan;
95(2):692-9.
PMID: 10627481
Alternative splicing plays a major role in regulating tissue-specific expression of cytoskeletal protein 4.1R isoforms. In particular, expression of the protein's functionally critical spectrin-actin binding domain, essential for maintenance of...
7.
Walensky L, Blackshaw S, Liao D, Watkins C, Weier H, Parra M, et al.
J Neurosci
. 1999 Jul;
19(15):6457-67.
PMID: 10414974
We report the molecular cloning and characterization of 4.1N, a novel neuronal homolog of the erythrocyte membrane cytoskeletal protein 4.1 (4.1R). The 879 amino acid protein shares 70, 36, and...
8.
Gascard P, Nunomura W, Lee G, Walensky L, Krauss S, Takakuwa Y, et al.
Mol Biol Cell
. 1999 Jun;
10(6):1783-98.
PMID: 10359596
The erythroid membrane cytoskeletal protein 4.1 is the prototypical member of a genetically and topologically complex family that is generated by combinatorial alternative splicing pathways and is localized at diverse...
9.
Shi Z, Afzal V, Coller B, Patel D, Chasis J, Parra M, et al.
J Clin Invest
. 1999 Feb;
103(3):331-40.
PMID: 9927493
A diverse family of protein 4.1R isoforms is encoded by a complex gene on human chromosome 1. Although the prototypical 80-kDa 4.1R in mature erythrocytes is a key component of...
10.
Gascard P, Lee G, Coulombel L, Auffray I, Lum M, Parra M, et al.
Blood
. 1998 Dec;
92(11):4404-14.
PMID: 9834247
In erythrocytes, 80-kD protein 4.1R regulates critical membrane properties of deformability and mechanical strength. However, previously obtained data suggest that multiple isoforms of protein 4. 1, generated by alternative pre-mRNA...