J Fraser Wright
Overview
Explore the profile of J Fraser Wright including associated specialties, affiliations and a list of published articles.
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Articles
70
Citations
8483
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Recent Articles
1.
Bornstein S, Wright J, Steenblock C
Nat Rev Endocrinol
. 2024 Aug;
20(11):627-628.
PMID: 39209975
No abstract available.
2.
Wright J
Mol Ther Methods Clin Dev
. 2023 Aug;
30:332.
PMID: 37637383
[This corrects the article DOI: 10.1016/j.omtm.2023.02.008.].
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Lee E, Shah D, Porteus M, Wright J, Bacchetta R
Cytotherapy
. 2022 Mar;
24(6):590-596.
PMID: 35227602
Background Aims: Cell therapies are costlier to manufacture than small molecules and protein therapeutics because they require multiple manipulations and are often produced in an autologous manner. Strategies to lower...
7.
Lisowski L, Staber J, Wright J, Valentino L
Res Pract Thromb Haemost
. 2021 Sep;
5(6):e12586.
PMID: 34485808
Gene therapy is at the forefront of the drive to bring the potential of cure to patients with genetic diseases. Multiple mechanisms of effective and efficient gene therapy delivery (eg,...
8.
Lattanzi A, Camarena J, Lahiri P, Segal H, Srifa W, Vakulskas C, et al.
Sci Transl Med
. 2021 Jun;
13(598).
PMID: 34135108
Sickle cell disease (SCD) is the most common serious monogenic disease with 300,000 births annually worldwide. SCD is an autosomal recessive disease resulting from a single point mutation in codon...
9.
Hamilton B, Wright J
Front Immunol
. 2021 Jun;
12:675897.
PMID: 34084173
Host immune responses that limit durable therapeutic gene expression and cause clinically significant inflammation remain a major barrier to broadly successful development of adeno-associated virus (AAV)-based human gene therapies. In...
10.
Wright J
Biotechnol J
. 2020 Nov;
16(1):e2000022.
PMID: 33146911
For adeno-associated virus (AAV)-based human gene therapy, challenges for the translation of promising research results to successful clinical development include optimization of vector design and manufacturing processes to ensure that...