J F Amara
Overview
Explore the profile of J F Amara including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
16
Citations
1173
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Amara J, Courage N, Gilman M
Hum Gene Ther
. 1999 Nov;
10(16):2651-5.
PMID: 10566892
Many therapeutic uses of gene-modified cells could benefit from inclusion of a surface marker for immunoselecting transduced cells. Another desired feature is a failsafe mechanism to ablate engineered cells if...
2.
Keenan T, Yaeger D, Courage N, Rollins C, Pavone M, Rivera V, et al.
Bioorg Med Chem
. 1998 Oct;
6(8):1309-35.
PMID: 9784872
The total synthesis and in vitro activities of a series of chemical inducers of dimerization (CIDs) is described. The use of small-molecule CIDs to control the dimerization of engineered FKBP12-containing...
3.
Clackson T, Yang W, Rozamus L, Hatada M, Amara J, Rollins C, et al.
Proc Natl Acad Sci U S A
. 1998 Sep;
95(18):10437-42.
PMID: 9724721
FKBP ligand homodimers can be used to activate signaling events inside cells and animals that have been engineered to express fusions between appropriate signaling domains and FKBP. However, use of...
4.
Amara J, Clackson T, Rivera V, Guo T, Keenan T, Natesan S, et al.
Proc Natl Acad Sci U S A
. 1997 Oct;
94(20):10618-23.
PMID: 9380684
The use of low molecular weight organic compounds to induce dimerization or oligomerization of engineered proteins has wide-ranging utility in biological research as well as in gene and cell therapies....
5.
Rivera V, Clackson T, Natesan S, Pollock R, Amara J, Keenan T, et al.
Nat Med
. 1996 Sep;
2(9):1028-32.
PMID: 8782462
Gene therapy was originally conceived as a medical intervention to replace or correct defective genes in patients with inherited disorders. However, it may have much broader potential as an alternative...
6.
Reisin I, Prat A, Abraham E, Amara J, Gregory R, Ausiello D, et al.
J Biol Chem
. 1994 Aug;
269(32):20584-91.
PMID: 7519611
The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to a superfamily of proteins implicated in the transport of ions, proteins, and hydrophobic substances. Recent studies have demonstrated that CFTR is...
7.
Cantiello H, Prat A, Reisin I, Ercole L, Abraham E, Amara J, et al.
J Biol Chem
. 1994 Apr;
269(15):11224-32.
PMID: 7512560
The cystic fibrosis transmembrane conductance regulator (CFTR) is a Cl- channel activated by protein kinase A and regulated by ATP in a complex manner. We have applied patch-clamp techniques to...
8.
Marshall J, Fang S, Ostedgaard L, ORiordan C, Ferrara D, Amara J, et al.
J Biol Chem
. 1994 Jan;
269(4):2987-95.
PMID: 7507932
We have generated several clones of Chinese hamster ovary, mouse epitheloid C127, and pig kidney epithelial LLCPK1 cells producing high levels of functional recombinant human cystic fibrosis transmembrane conductance regulator...
9.
Denning G, Anderson M, Amara J, Marshall J, Smith A, Welsh M
Nature
. 1992 Aug;
358(6389):761-4.
PMID: 1380673
Cystic fibrosis transmembrane conductance regulator (CFTR) is a plasma membrane Cl- channel regulated by cyclic AMP-dependent phosphorylation and by intracellular ATP. Mutations in CFTR cause cystic fibrosis partly through loss...
10.
Amara J, Cheng S, Smith A
Trends Cell Biol
. 1992 May;
2(5):145-9.
PMID: 14731969
Secretory proteins and integral membrane proteins travel through the secretory pathway to a variety of destinations. Their targets are often specified by signals in the amino acid sequence or signals...