J E Toth
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Explore the profile of J E Toth including associated specialties, affiliations and a list of published articles.
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21
Citations
124
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Recent Articles
1.
Schmidt A, Wu H, MacKenzie R, Chen V, Bewly J, Ray J, et al.
Biochemistry
. 2000 Jun;
39(21):6325-35.
PMID: 10828945
Enzymes involved in tetrahydrofolate metabolism are of particular pharmaceutical interest, as their function is crucial for amino acid and DNA biosynthesis. The crystal structure of the human cytosolic methylenetetrahydrofolate dehydrogenase/cyclohydrolase...
2.
Sall D, Bailey D, Bastian J, Buben J, Chirgadze N, Denney M, et al.
J Med Chem
. 2000 Feb;
43(4):649-63.
PMID: 10691691
A systematic investigation of the structure-activity relationships of the C-3 side chain of the screening hit 1a led to the identification of the potent thrombin inhibitors 23c, 28c, and 31c....
3.
Varie D, Shih C, Hay D, Andis S, Corbett T, Gossett L, et al.
Bioorg Med Chem Lett
. 1999 Mar;
9(3):369-74.
PMID: 10091686
Analogs of the antitumor agents cryptophycins 1 and 8 with dialkyl substitution at C-6 (fragment C) were synthesized and evaluated for in vitro cytotoxicity against human leukemia cells (CCRF-CEM). The...
4.
Tonkinson J, Habeck L, Toth J, Mendelsohn L, Bewley J, Shackelford K, et al.
J Pharmacol Exp Ther
. 1998 Oct;
287(1):315-21.
PMID: 9765352
5,6,7,8-Tetrahydro-N5,N10-carbonylfolic acid (LY354899) has been demonstrated to inhibit the dehydrogenase activity of C1-tetrahydrofolate synthase. This compound was only moderately antiproliferative toward CCRF-CEM lymphocytic leukemia cells in culture, but induced apoptosis...
5.
Ehlhardt W, Woodland J, Toth J, Ray J, Martin D
Drug Metab Dispos
. 1997 Jun;
25(6):701-8.
PMID: 9193871
The disposition and metabolism of LY295501 was studied in mice, rats, and monkeys. This novel diaryl sulfonylurea oncolytic agent is structurally related to sulofenur and shows excellent activity in a...
6.
Toth J, GRINDEY G, Ehlhardt W, Ray J, Boder G, Bewley J, et al.
J Med Chem
. 1997 Mar;
40(6):1018-25.
PMID: 9083492
A series of sulfonimidamide analogs of the oncolytic diarylsulfonylureas was synthesized and evaluated for (1) in vitro cytotoxicity against CEM cells, (2) in vivo antitumor activity against subaxillary implanted 6C3HED...
7.
Norman B, Shih C, Toth J, Ray J, Dodge J, Johnson D, et al.
J Med Chem
. 1996 Mar;
39(5):1106-11.
PMID: 8676346
Wortmannin, a fungal metabolite, was identified as a potent inhibitor (IC50 = 4.2 nM) of phosphatidylinositol 3-kinase (PI 3-kinase). Due to the importance of PI 3-kinase in several intracellular signaling...
8.
Schultz R, Andis S, Toth J, Boder G, Rinzel S, GRINDEY G
Anticancer Res
. 1993 Nov;
13(6A):1939-43.
PMID: 8297099
Several diarylsulfonylureas (DSU), including Sulofenur (LY186641) and LY181984, have been described that exhibit wide spectrum and high therapeutic activity against murine solid tumors and human tumor xenografts. The mechanism for...
9.
Schultz R, Merriman R, Toth J, Zimmermann J, Hertel L, Andis S, et al.
Oncol Res
. 1993 Jan;
5(6-7):223-8.
PMID: 8123942
Human pancreatic carcinoma xenograft models were developed from established MIA PaCa-2 and PANC-1 cell lines (ATCC, Rockville, MD). Tumors were maintained by serial trocar implantation in CD1 nu/nu mice, and...
10.
Rush G, Rinzel S, Boder G, Heim R, Toth J, Ponsler G
Biochem Pharmacol
. 1992 Dec;
44(12):2387-94.
PMID: 1472104
Diarylsulfonylureas, such as N-(4-chlorophenyl)aminocarbonyl-2,3-dihydro-1-indene-5-sulfonamide (LY186641, Sulofenur) and N-(4-chlorophenyl)aminocarbonyl-4-methylbenzene sulfonamide (LY181984), have been shown to be effective antitumor agents in a variety of in vivo and in vitro animal models. Their...