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J D Lambris

Explore the profile of J D Lambris including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 135
Citations 3167
Followers 0
Related Specialties
Allergy & Immunology
Biochemistry
General Medicine
Top 10 Co-Authors
A Sahu
J Alsenz
J D Becherer
G H Cohen
R J Eisenberg
W T MOORE
J O Sunyer
G D Ross
M R Sarrias
T E Mollnes
Published In
J Immunol
J Virol
Biochem J
J Exp Med
Eur J Immunol
Affiliations
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Recent Articles
1.
Complement C5a-Induced Changes in Neutrophil Morphology During Inflammation
Denk S, Taylor R, Wiegner R, Cook E, Lindorfer M, Pfeiffer K, et al.
Scand J Immunol . 2017 Jul; 86(3):143-155. PMID: 28671713
The complement and neutrophil defence systems, as major components of innate immunity, are activated during inflammation and infection. For neutrophil migration to the inflamed region, we hypothesized that the complement...
2.
Differential capacity for complement receptor-mediated immune evasion by Porphyromonas gingivalis depending on the type of innate leukocyte
Hajishengallis G, Krauss J, Jotwani R, Lambris J
Mol Oral Microbiol . 2016 Apr; 32(2):154-165. PMID: 27081768
The complement system plays a central role in immunity and inflammation, although certain pathogens can exploit complement to undermine protective immunity. In this context, the periodontal keystone pathogen Porphyromonas gingivalis...
3.
Complement therapeutics in inflammatory diseases: promising drug candidates for C3-targeted intervention
Mastellos D, Ricklin D, Hajishengallis E, Hajishengallis G, Lambris J
Mol Oral Microbiol . 2015 Sep; 31(1):3-17. PMID: 26332138
There is increasing appreciation that complement dysregulation lies at the heart of numerous immune-mediated and inflammatory disorders. Complement inhibitors are therefore being evaluated as new therapeutic options in various clinical...
4.
Complement inhibition in a xenogeneic model of interactions between human whole blood and porcine endothelium
Kourtzelis I, Ferreira A, Mitroulis I, Ricklin D, Bornstein S, Waskow C, et al.
Horm Metab Res . 2014 Oct; 47(1):36-42. PMID: 25350518
Xenotransplantation (xeno-Tx) is considered as an alternative solution to overcome the shortage of human donor organs. However, the success of xeno-Tx is hindered by immune reactions against xenogeneic cells (e. ...
5.
C1-inhibitor efficiently inhibits Escherichia coli-induced tissue factor mRNA up-regulation, monocyte tissue factor expression and coagulation activation in human whole blood
Landsem A, Nielsen E, Fure H, Christiansen D, Ludviksen J, Lambris J, et al.
Clin Exp Immunol . 2013 Apr; 173(2):217-29. PMID: 23607270
Both the complement system and tissue factor (TF), a key initiating component of coagulation, are activated in sepsis, and cross-talk occurs between the complement and coagulation systems. C1-inhibitor (C1-INH) can...
6.
Differential effect of inhibiting MD-2 and CD14 on LPS- versus whole E. coli bacteria-induced cytokine responses in human blood
Christiansen D, Brekke O, Stenvik J, Lambris J, Espevik T, Mollnes T
Adv Exp Med Biol . 2011 Sep; 946:237-51. PMID: 21948372
Background: Sepsis is a major world-wide medical problem with high morbidity and mortality. Gram-negative bacteria are among the most important pathogens of sepsis and their LPS content is regarded to...
7.
An ex vivo loop system models the toxicity and efficacy of PEGylated and unmodified adenovirus serotype 5 in whole human blood
Danielsson A, Elgue G, Nilsson B, Nilsson B, Lambris J, Totterman T, et al.
Gene Ther . 2010 Mar; 17(6):752-62. PMID: 20220781
Polyethylene glycol coating (PEGylation) of adenovirus serotype 5 (Ad5) has been shown to effectively reduce immunogenicity and increase circulation time of intravenously administered virus in mouse models. Herein, we monitored...
8.
Complement activation triggered by chondroitin sulfate released by thrombin receptor-activated platelets
Hamad O, Ekdahl K, Nilsson P, Andersson J, Magotti P, Lambris J, et al.
J Thromb Haemost . 2008 May; 6(8):1413-21. PMID: 18503629
Background: Chondroitin sulfate (CS) is a glycosaminoglycan released by activated platelets. Objective: Here we test the hypothesis that CS released by activated platelets can trigger complement activation in the fluid...
9.
The artificial surface-induced whole blood inflammatory reaction revealed by increases in a series of chemokines and growth factors is largely complement dependent
Lappegard K, Bergseth G, Riesenfeld J, Pharo A, Magotti P, Lambris J, et al.
J Biomed Mater Res A . 2007 Dec; 87(1):129-35. PMID: 18085644
Exposing blood to an artificial surface results in a systemic inflammatory response, including cytokine release and complement activation. We studied the artificial surface-induced inflammation in human whole blood using an...
10.
CD59 efficiently protects human NT2-N neurons against complement-mediated damage
Pedersen E, Aass H, Rootwelt T, Fung M, Lambris J, Mollnes T
Scand J Immunol . 2007 Jul; 66(2-3):345-51. PMID: 17635812
The complement regulatory protein CD59 controls cell survival by the inhibition of C5b-9 formation on the cell membrane. Loss of CD59 increases the susceptibility of cells to complement-mediated damage and...