J Christopher Luft
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Explore the profile of J Christopher Luft including associated specialties, affiliations and a list of published articles.
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48
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1802
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Recent Articles
1.
Yi X, Wang Y, Jia Z, Hiller S, Nakamura J, Luft J, et al.
J Biomed Nanotechnol
. 2020 Sep;
16(4):467-480.
PMID: 32970979
We developed a vaccine formulation containing ApoB derived P210 peptides as autoantigens, retinoic acid (RA) as an immune enhancer, both of which were delivered using PLGA nanoparticles. The formula was...
2.
Tian S, Nakamura J, Hiller S, Simington S, Holley D, Mota R, et al.
Vascul Pharmacol
. 2020 Aug;
133-134:106777.
PMID: 32750408
Atherosclerosis is a systemic chronic inflammatory disease. Many antioxidants including alpha-lipoic acid (LA), a product of lipoic acid synthase (Lias), have proven to be effective for treatment of this disease....
3.
Perry J, Tian S, Sengottuvel N, Harrison E, Gorentla B, Kapadia C, et al.
ACS Nano
. 2020 May;
14(6):7200-7215.
PMID: 32463690
CpG oligodeoxynucleotides are potent toll-like receptor (TLR) 9 agonists and have shown promise as anticancer agents in preclinical studies and clinical trials. Binding of CpG to TLR9 initiates a cascade...
4.
Kapadia C, Tian S, Perry J, Luft J, DeSimone J
ACS Omega
. 2019 Apr;
4(3):5547-5555.
PMID: 30972374
Multiple studies have been published emphasizing the significant role of nanoparticle (NP) carriers in antigenic peptide-based subunit vaccines for the induction of potent humoral and cellular responses. Various design parameters...
5.
Dunn S, Luft J, Parrott M
Nanoscale
. 2019 Jan;
11(4):1847-1855.
PMID: 30637420
The starting hypothesis for this work was that microwave synthesis could enable the rapid assembly of polymers into size-specific nanoparticles (NPs). The Zapped Assembly of Polymeric (ZAP) NPs was initially...
6.
Glatt D, Beckford Vera D, Prabhu S, Mumper R, Luft J, Benhabbour S, et al.
Mol Pharm
. 2018 Sep;
15(11):5089-5102.
PMID: 30226780
The safety and efficacy of anticancer antibody-drug conjugates (ADCs) depend on the selection of tumor-targeting monoclonal antibody (mAb), linker, and drug, as well as their specific chemical arrangement and linkage...
7.
Wilson E, Luft J, DeSimone J
Pharm Res
. 2018 Aug;
35(10):195.
PMID: 30141117
Purpose: Pulmonary delivery of biologics is of great interest, as it can be used for the local treatment of respiratory diseases or as a route to systemic drug delivery. To...
8.
Caudill C, Perry J, Tian S, Luft J, DeSimone J
J Control Release
. 2018 Jun;
284:122-132.
PMID: 29894710
Microneedle patches, arrays of micron-scale projections that penetrate skin in a minimally invasive manner, are a promising tool for transdermally delivering therapeutic proteins. However, current microneedle fabrication techniques are limited...
9.
Coffman J, Metz S, Brackbill A, Paul M, Miley M, DeSimone J, et al.
Bioconjug Chem
. 2018 Apr;
29(5):1544-1552.
PMID: 29701995
The dengue virus (DENV) causes over 350 million infections, resulting in ∼25,000 deaths per year globally. An effective dengue vaccine requires generation of strong and balanced neutralizing antibodies against all...
10.
Byrne J, Jajja M, ONeill A, Schorzman A, Keeler A, Luft J, et al.
Cancer Chemother Pharmacol
. 2018 Apr;
81(6):991-998.
PMID: 29603014
Purpose: Effective treatment of patients with locally advanced pancreatic cancer is a significant unmet clinical need. One major hurdle that exists is inadequate drug delivery due to the desmoplastic stroma...