J C Philcox
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Explore the profile of J C Philcox including associated specialties, affiliations and a list of published articles.
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39
Citations
586
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Recent Articles
1.
Coyle P, Mathew G, Game P, Myers J, Philcox J, Rofe A, et al.
Br J Cancer
. 2002 Aug;
87(5):533-6.
PMID: 12189552
The potential of the metal-binding protein, metallothionein, in assessing the progression of normal oesophagus through Barrett's to adenocarcinoma was investigated. Metallothionein was quantitatively determined in resected tissues from patients undergoing...
2.
Coyle P, Philcox J, Carey L, Rofe A
Cell Mol Life Sci
. 2002 May;
59(4):627-47.
PMID: 12022471
Metallothioneins (MTs) are intracellular, low molecular, low molecular weight, cysteine-rich proteins. Ubiquitous in eukaryotes, MTs have unique structural characteristics to give potent metal-binding and redox capabilities. A primary role has...
3.
Coyle P, Hubert C, Philcox J, Rofe A
Biol Trace Elem Res
. 2001 Sep;
81(3):269-78.
PMID: 11575683
We examined the storage stability of metallothionein (MT), a cysteine-rich protein that has diagnostic potential as a cancer marker and in the assessment of Zn status and heavy-metal toxicity. MT...
4.
Hinskens B, Philcox J, Coyle P, Rofe A
Biol Trace Elem Res
. 2001 Apr;
78(1-3):231-40.
PMID: 11314981
Metallothionein (MT) has been assigned a role in intestinal Zn absorption and secretion. The influence of MT was investigated in isolated segments of the small intestine from mice lacking the...
5.
Rofe A, Philcox J, Coyle P
Biol Trace Elem Res
. 2000 Oct;
75(1-3):87-97.
PMID: 11051599
The influence of hepatic metallothionein (MT) and zinc (Zn) on glycolysis was investigated in primary cultures of mouse hepatocytes prepared from MT-normal (+/+) and MT-null (-/-) mice. In MT +/+...
6.
Coyle P, Niezing G, Shelton T, Philcox J, Rofe A
Toxicology
. 2000 Sep;
150(1-3):53-67.
PMID: 10996663
The protective role of metallothionein (MT) in Cd-mediated hepatotoxicity was investigated in vivo and in vitro. Following injection of Cd (2 mg/kg, intraperitoneal or subcutaneous) hepatoxicity was significantly greater at...
7.
Carey L, Coyle P, Philcox J, Rofe A
Alcohol Clin Exp Res
. 2000 Sep;
24(8):1236-40.
PMID: 10968663
Background: Ethanol causes significant teratogenicity in normal (MT+/+) but not metallothionein-null (MT-/-) fetuses. Impaired maternal fetal zinc (Zn) transfer is indicated, because ethanol significantly reduces plasma Zn concentrations in MT+/+...
8.
Philcox J, Sturkenboom M, Coyle P, Rofe A
J Nutr
. 2000 Aug;
130(8):1901-9.
PMID: 10917900
Normal metallothionein [(MT)+/+] and MT-null (MT-/-) mice were used to examine the influence of MT on Zn retention and the metabolic consequences of 2 d food deprivation, with and without...
9.
Coyle P, Philcox J, Rofe A
J Nutr
. 2000 Mar;
130(4):835-42.
PMID: 10736338
The influence of metallothionein (MT)(2) on Zn absorption was investigated in MT-null (MT-/-) and normal (MT+/+) mice fed Zn-depleted (ZnD) diets for 7 d and compared with those fed Zn-replete...
10.
Carey L, Coyle P, Philcox J, Rofe A
Alcohol Clin Exp Res
. 2000 Mar;
24(2):213-9.
PMID: 10698374
Background: Ethanol profoundly affects fetal development, and this is proposed to be due primarily to a transient fetal zinc (Zn) deficiency that arises from the binding of Zn by metallothionein...