J C Heimbach
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Explore the profile of J C Heimbach including associated specialties, affiliations and a list of published articles.
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9
Citations
638
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Recent Articles
1.
Tucker T, Lumma Jr W, Payne L, Wai J, de Solms S, Giuliani E, et al.
J Med Chem
. 1992 Jul;
35(14):2525-33.
PMID: 1635054
A series of HIV-1 protease inhibitors containing a novel hydroxyethyl secondary amine transition state isostere has been synthesized. The compounds exhibit a strong preference for the (R) stereochemistry at the...
2.
Herber W, Bailey F, Carty C, Heimbach J, Maigetter R
Appl Microbiol Biotechnol
. 1991 Nov;
36(2):149-52.
PMID: 1368104
Two fermentation processes for the tryptophan-regulated expression of active HIV protease (HIV-1 prt) in Escherichia coli are described. Since overexpression of HIV-1 prt results in cell death, stringent control of...
3.
Darke P, Kohl N, Hanobik M, Leu C, Vacca J, Guare J, et al.
Adv Exp Med Biol
. 1991 Jan;
306:483-7.
PMID: 1812746
No abstract available.
4.
Fitzgerald P, McKeever B, VanMiddlesworth J, Springer J, Heimbach J, Leu C, et al.
J Biol Chem
. 1990 Aug;
265(24):14209-19.
PMID: 2201682
The mode of binding of acetyl-pepstatin to the protease from the human immunodeficiency virus type 1 (HIV-1) has been determined by x-ray diffraction analysis. Crystals of an acetyl-pepstatin-HIV-1 protease complex...
5.
Heimbach J, Garsky V, Michelson S, Dixon R, Sigal I, Darke P
Biochem Biophys Res Commun
. 1989 Nov;
164(3):955-60.
PMID: 2686642
An inhibitor of the HIV-1 protease has been employed in the generation of a resin which allows the rapid purification of this enzyme. A peptide substrate analogue, H2N-Ser-Gln-Asn-(Phe-psi[CH2N]-Pro)-Ile-Val-Gln-OH, was coupled...
6.
Navia M, Fitzgerald P, McKeever B, Leu C, Heimbach J, Herber W, et al.
Nature
. 1989 Feb;
337(6208):615-20.
PMID: 2645523
The crystal structure of the protease of the human immunodeficiency virus type (HIV-1), which releases structural proteins and enzymes from viral polyprotein products, has been determined to 3 A resolution....
7.
Darke P, Leu C, Davis L, Heimbach J, Diehl R, HILL W, et al.
J Biol Chem
. 1989 Feb;
264(4):2307-12.
PMID: 2644259
The protease of human immunodeficiency virus has been expressed in Escherichia coli and purified to apparent homogeneity. Immunoreactivity toward anti-protease peptide sera copurified with an activity that cleaved the structural...
8.
McKeever B, Navia M, Fitzgerald P, Springer J, Leu C, Heimbach J, et al.
J Biol Chem
. 1989 Feb;
264(4):1919-21.
PMID: 2644246
The aspartylprotease of the human immunodeficiency virus HIV-1 (NY5) has been crystallized in a form suitable for x-ray diffraction analysis. The crystals are tetragonal bipyramids and produce an x-ray diffraction...
9.
Kohl N, Emini E, Schleif W, Davis L, Heimbach J, Dixon R, et al.
Proc Natl Acad Sci U S A
. 1988 Jul;
85(13):4686-90.
PMID: 3290901
Retroviral proteins are synthesized as polyprotein precursors that undergo proteolytic cleavages to yield the mature viral proteins. The role of the human immunodeficiency virus (HIV) protease in the viral replication...