J Brent Richards
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Explore the profile of J Brent Richards including associated specialties, affiliations and a list of published articles.
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221
Citations
16027
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Recent Articles
21.
Zhou S, Sosina O, Bovijn J, Laurent L, Sharma V, Akbari P, et al.
Nat Genet
. 2023 Aug;
55(8):1277-1287.
PMID: 37558884
In this study, we leveraged the combined evidence of rare coding variants and common alleles to identify therapeutic targets for osteoporosis. We undertook a large-scale multiancestry exome-wide association study for...
22.
Butler-Laporte G, Auckland K, Noor Z, Kabir M, Alam M, Carstensen T, et al.
medRxiv
. 2023 Jul;
PMID: 37425840
Hepatitis B virus (HBV) vaccine escape mutants (VEM) are increasingly described, threatening progress in control of this virus worldwide. Here we studied the relationship between host genetic variation, vaccine immunogenicity...
23.
Medina-Gomez C, Mullin B, Chesi A, Prijatelj V, Kemp J, Shochat-Carvalho C, et al.
Commun Biol
. 2023 Jul;
6(1):691.
PMID: 37402774
Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes in bone biology, particularly to intramembranous ossification, not captured at other skeletal sites. We perform...
24.
Lu T, Nakanishi T, Yoshiji S, Butler-Laporte G, Greenwood C, Richards J
J Clin Endocrinol Metab
. 2023 Jun;
108(12):3320-3329.
PMID: 37368847
Context: Effects of modest alcohol consumption remain controversial. Mendelian randomization (MR) can help to mitigate biases due to confounding and reverse causation in observational studies, and evaluate the potential causal...
25.
Han X, Lains I, Li J, Li J, Chen Y, Yu B, et al.
Cell Rep Med
. 2023 Jun;
4(7):101085.
PMID: 37348500
Age-related macular degeneration (AMD) is a leading cause of blindness in older adults. Investigating shared genetic components between metabolites and AMD can enhance our understanding of its pathogenesis. We conduct...
26.
Su C, Zhou S, Gonzalez-Kozlova E, Butler-Laporte G, Brunet-Ratnasingham E, Nakanishi T, et al.
Sci Rep
. 2023 Apr;
13(1):6236.
PMID: 37069249
Predicting COVID-19 severity is difficult, and the biological pathways involved are not fully understood. To approach this problem, we measured 4701 circulating human protein abundances in two independent cohorts totaling...
27.
Liang K, Farjoun Y, Forgetta V, Chen Y, Yoshiji S, Lu T, et al.
Hum Genet
. 2023 Apr;
142(6):749-758.
PMID: 37009933
GWAS has identified thousands of loci associated with disease, yet the causal genes within these loci remain largely unknown. Identifying these causal genes would enable deeper understanding of the disease...
28.
Nadkami G, Paranjpe I, Jayaraman P, Su C, Zhou S, Chen S, et al.
Res Sq
. 2023 Mar;
PMID: 36993735
Acute kidney injury (AKI) is a known complication of COVID-19 and is associated with an increased risk of in-hospital mortality. Unbiased proteomics using biological specimens can lead to improved risk...
29.
Yoshiji S, Butler-Laporte G, Lu T, Willett J, Su C, Nakanishi T, et al.
Nat Metab
. 2023 Feb;
5(2):248-264.
PMID: 36805566
Obesity is a major risk factor for Coronavirus disease (COVID-19) severity; however, the mechanisms underlying this relationship are not fully understood. As obesity influences the plasma proteome, we sought to...
30.
Butler-Laporte G, Farjoun Y, Chen Y, Hultstrom M, Liang K, Nakanishi T, et al.
Int J Epidemiol
. 2023 Feb;
52(4):1163-1174.
PMID: 36773317
Objectives: Increased iron stores have been associated with elevated risks of different infectious diseases, suggesting that iron supplementation may increase the risk of infections. However, these associations may be biased...