J Brent Richards
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Explore the profile of J Brent Richards including associated specialties, affiliations and a list of published articles.
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16027
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Recent Articles
11.
Sasako T, Ilboudo Y, Liang K, Chen Y, Yoshiji S, Richards J
J Clin Endocrinol Metab
. 2024 May;
109(12):3234-3244.
PMID: 38701087
Context: Trinucleotide repeats in the androgen receptor have been proposed to influence testosterone signaling in men, but the clinical relevance of these trinucleotide repeats remains controversial. Objective: To examine how...
12.
Austin T, Fink H, Jalal D, Tornqvist A, Buzkova P, Barzilay J, et al.
J Bone Miner Res
. 2024 Mar;
39(2):139-149.
PMID: 38477735
Hip fractures are associated with significant disability, high cost, and mortality. However, the exact biological mechanisms underlying susceptibility to hip fractures remain incompletely understood. In an exploratory search of the...
13.
Sterenborg R, Steinbrenner I, Li Y, Bujnis M, Naito T, Marouli E, et al.
Nat Commun
. 2024 Jan;
15(1):888.
PMID: 38291025
To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals...
14.
Butler-Laporte G, Farjoun J, Nakanishi T, Lu T, Abner E, Chen Y, et al.
Commun Biol
. 2023 Nov;
6(1):1113.
PMID: 37923823
The human leukocyte antigen (HLA) region on chromosome 6 is strongly associated with many immune-mediated and infection-related diseases. Due to its highly polymorphic nature and complex linkage disequilibrium patterns, traditional...
15.
Nethander M, Moverare-Skrtic S, Kampe A, Coward E, Reimann E, Grahnemo L, et al.
Nat Genet
. 2023 Nov;
55(11):1820-1830.
PMID: 37919453
Osteoporotic fracture is among the most common and costly of diseases. While reasonably heritable, its genetic determinants have remained elusive. Forearm fractures are the most common clinically recognized osteoporotic fractures...
16.
Lu T, Forgetta V, Zhou S, Richards J, Greenwood C
J Bone Miner Res
. 2023 Oct;
38(12):1771-1781.
PMID: 37830501
Osteoporosis and fractures severely impact the elderly population. Polygenic risk scores for bone mineral density have demonstrated potential clinical utility. However, the value of rare genetic determinants in risk prediction...
17.
Nakanishi T, Willett J, Farjoun Y, Allen R, Guillen-Guio B, Adra D, et al.
Nat Commun
. 2023 Oct;
14(1):6198.
PMID: 37794074
Alternative splicing generates functional diversity in isoforms, impacting immune response to infection. Here, we evaluate the causal role of alternative splicing in COVID-19 severity and susceptibility by applying two-sample Mendelian...
18.
Willett J, Lu T, Nakanishi T, Yoshiji S, Butler-Laporte G, Zhou S, et al.
Hum Genet
. 2023 Aug;
142(10):1461-1476.
PMID: 37640912
Identifying causal genes at GWAS loci can help pinpoint targets for therapeutic interventions. Expression studies can disentangle such loci but signals from expression quantitative trait loci (eQTLs) often fail to...
19.
Trajanoska K, Bherer C, Taliun D, Zhou S, Richards J, Mooser V
Nature
. 2023 Aug;
620(7975):737-745.
PMID: 37612393
The substantial investments in human genetics and genomics made over the past three decades were anticipated to result in many innovative therapies. Here we investigate the extent to which these...
20.
Mullin B, Zhu K, Brown S, Mullin S, Dudbridge F, Pavlos N, et al.
Genetics
. 2023 Aug;
225(2).
PMID: 37579195
There has been a growing interest in the role of the subchondral bone and its resident osteoclasts in the progression of osteoarthritis (OA). A recent genome-wide association study (GWAS) identified...