J Bradley Zuchero
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Explore the profile of J Bradley Zuchero including associated specialties, affiliations and a list of published articles.
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36
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2278
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Recent Articles
1.
Lan T, Ambiel N, Lee Y, Nonomura T, Zhou Y, Zuchero J
Small Methods
. 2025 Jan;
:e2401522.
PMID: 39891215
The actin cytoskeleton and its nanoscale organization are central to all eukaryotic cells-powering diverse cellular functions including morphology, motility, and cell division-and is dysregulated in multiple diseases. Historically studied largely...
2.
Markusson S, Raasakka A, Schroder M, Sograte-Idrissi S, Rahimi A, Asadpour O, et al.
J Neurochem
. 2024 Dec;
169(1):e16274.
PMID: 39655780
2',3'-Cyclic nucleotide 3'-phosphodiesterase (CNPase) is an abundant constituent of central nervous system non-compact myelin, and its loss in mice and humans causes neurodegeneration. Additionally, CNPase is frequently used as a...
3.
Kantarci H, Elvira P, Thottumkara A, OConnell E, Iyer M, Donovan L, et al.
Cell
. 2024 Aug;
187(17):4690-4712.e30.
PMID: 39142281
Electrical excitability-the ability to fire and propagate action potentials-is a signature feature of neurons. How neurons become excitable during development and whether excitability is an intrinsic property of neurons remain...
4.
Song J, Saglam A, Zuchero J, Buch V
Brain Sci
. 2024 Jul;
14(7).
PMID: 39061389
The central nervous system (CNS) exhibits remarkable adaptability throughout life, enabled by intricate interactions between neurons and glial cells, in particular, oligodendrocytes (OLs) and oligodendrocyte precursor cells (OPCs). This adaptability...
5.
Markusson S, Raasakka A, Schroder M, Sograte-Idrissi S, Rahimi A, Asadpour O, et al.
bioRxiv
. 2024 Jun;
PMID: 38826303
2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) is an abundant constituent of central nervous system non-compact myelin, frequently used as a marker antigen for myelinating cells. The catalytic activity of CNPase, the 3'-hydrolysis...
6.
OShaughnessy E, Lam M, Ryken S, Wiesner T, Lukasik K, Zuchero J, et al.
J Cell Sci
. 2024 May;
137(20).
PMID: 38690758
Exocytosis is a fundamental process used by eukaryotes to regulate the composition of the plasma membrane and facilitate cell-cell communication. To investigate exocytosis in neuronal morphogenesis, previously we developed computational...
7.
Veprek N, Cooper M, Laprell L, Yang E, Folkerts S, Bao R, et al.
J Am Chem Soc
. 2024 Mar;
146(13):8895-8903.
PMID: 38511265
Actin is one of the most abundant proteins in eukaryotic cells and is a key component of the cytoskeleton. A range of small molecules has emerged that interfere with actin...
8.
Iram T, Garcia M, Amand J, Kaur A, Atkins M, Iyer M, et al.
Proc Natl Acad Sci U S A
. 2024 Mar;
121(12):e2307250121.
PMID: 38483990
Myelination of neuronal axons is essential for nervous system development. Myelination requires dramatic cytoskeletal dynamics in oligodendrocytes, but how actin is regulated during myelination is poorly understood. We recently identified...
9.
Iyer M, Kantarci H, Cooper M, Ambiel N, Novak S, Andrade L, et al.
Nat Commun
. 2024 Jan;
15(1):265.
PMID: 38177161
Myelin is essential for rapid nerve signaling and is increasingly found to play important roles in learning and in diverse diseases of the CNS. Morphological parameters of myelin such as...
10.
Veprek N, Cooper M, Laprell L, Yang E, Folkerts S, Bao R, et al.
bioRxiv
. 2023 Jul;
PMID: 37502978
Actin is one of the most abundant proteins in eukaryotic cells and a key component of the cytoskeleton. A range of small molecules have emerged that interfere with actin dynamics...