J A Tino
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Explore the profile of J A Tino including associated specialties, affiliations and a list of published articles.
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6
Citations
71
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Recent Articles
1.
Ong L, Vasta J, Monereau L, Locke G, Ribeiro H, Pattoli M, et al.
SLAS Discov
. 2019 Nov;
25(2):176-185.
PMID: 31709883
Protein kinases are intensely studied mediators of cellular signaling. While traditional biochemical screens are capable of identifying compounds that modulate kinase activity, these assays are limited in their capability of...
2.
Wetterau J, GREGG R, Harrity T, Arbeeny C, Cap M, Connolly F, et al.
Science
. 1998 Oct;
282(5389):751-4.
PMID: 9784135
Patients with abetalipoproteinemia, a disease caused by defects in the microsomal triglyceride transfer protein (MTP), do not produce apolipoprotein B-containing lipoproteins. It was hypothesized that small molecule inhibitors of MTP...
3.
Chen P, Cheng P, Alam M, Beyer B, Bisacchi G, Dejneka T, et al.
J Med Chem
. 1996 May;
39(10):1991-2007.
PMID: 8642558
A series of novel aminodiol inhibitors of HIV protease based on the lead compound 1 with structural modifications at P1' were synthesized in order to reduce the cytotoxicity of 1....
4.
Bechtold C, Patick A, Alam M, Greytok J, Tino J, Chen P, et al.
Antimicrob Agents Chemother
. 1995 Feb;
39(2):374-9.
PMID: 7726501
A series of aminodiol inhibitors of human immunodeficiency virus type 1 (HIV-1) protease were identified by using an in vitro peptide cleavage assay. BMS 182,193, BMS 186,318, and BMS 187,071...
5.
Tino J, Clark J, Field A, Jacobs G, Lis K, Michalik T, et al.
J Med Chem
. 1993 Apr;
36(9):1221-9.
PMID: 8387600
A series of branched-chain sugar isonucleosides was synthesized and evaluated for antiviral activity against herpesviruses. The preparation of homochiral [3S-(3 alpha, 4 beta, 5 alpha)]-2-amino-1, 9-dihydro-9-[tetrahydro-4,5-bis(hydroxymethyl)-3-furanyl]-6H-purin-6-one (7, BMS-181,164) and related...
6.
Slusarchyk W, Bisacchi G, Field A, Hockstein D, Jacobs G, Tino J, et al.
J Med Chem
. 1992 May;
35(10):1799-806.
PMID: 1316966
A series of racemic (1 alpha (E), 2 beta, 3 alpha)-1-[2,3-bis(hydroxymethyl)cyclobutyl]-5-(2-halovinyl)uracils was synthesized and evaluated in cell culture. The bromovinyl, iodovinyl, and chlorovinyl analogues, 13, 15, and 16, respectively, are...