J A Ferrendelli
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Explore the profile of J A Ferrendelli including associated specialties, affiliations and a list of published articles.
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135
Citations
974
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Recent Articles
1.
Regulation of cyclic AMP levels in mammalian retina: Effects of depolarizing agents and transmitters
Blazynski C, deVries G, Geary K, Cohen A, Ferrendelli J
Neurochem Int
. 2010 May;
17(3):425-33.
PMID: 20504642
Cellular depolarization in brain results in a modulation of cAMP levels by releasing neurotransmitters having receptors linked via GTP-binding proteins to adenylate cyclase. In order to determine the transmitters regulating...
2.
Ferrendelli J, De Vries G, Cohen A, LOWRY O
Neurochem Int
. 2010 May;
1C:311-26.
PMID: 20487744
The distribution of cyclic GMP, cyclic AMP and related enzymes in the vertebrate retina, together with factors regulating their levels, are described. Photo-receptor cells in retinas from all species examined...
3.
Ferrendelli J, French J, Leppik I, Morrell M, Herbeuval A, Han J, et al.
Epilepsy Behav
. 2003 Dec;
4(6):702-9.
PMID: 14698704
Levetiracetam (Keppra) was evaluated in a subset of patients aged >/=65 years (n=78) enrolled in a large (n=1030) open-label, phase IV trial (the KEEPER trial). A 4-week dose adjustment was...
4.
Ferrendelli J
Epilepsia
. 2001 Sep;
42 Suppl 4:28-30.
PMID: 11564122
A number of commonly used antiepileptic drugs (AEDs) produce severe adverse effects if they are introduced at their usual daily maintenance doses. Gradual slow titration of the dose often avoids...
5.
Ferrendelli J
Epilepsia
. 1999 Oct;
40 Suppl 5:S81-3.
PMID: 10530698
Therapeutic options for epilepsy are increasing, and all drugs can produce adverse side effects. Physicians should first use monotherapy when treating an epileptic patient. If one drug proves insufficient to...
6.
Canney D, Lu H, McKeon A, Yoon K, Xu K, Holland K, et al.
Bioorg Med Chem
. 1998 Mar;
6(1):43-55.
PMID: 9502104
Dihydro-2(3H)-furanones (gamma-butyrolactones) and dihydro-2(3H)-thiophenones (gamma-thiobutyrolactones) containing fluoroalkyl groups at positions C-3, C-4, and C-5 of the heterocyclic rings were prepared. The anticonvulsant/convulsant activities of the compounds were evaluated in mice....
7.
Williams K, Tucker J, White G, Weiss D, Ferrendelli J, Covey D, et al.
Mol Pharmacol
. 1997 Jul;
52(1):114-9.
PMID: 9224820
The gamma-aminobutyric acid-A (GABA(A)) receptor complex is allosterically modulated by a variety of substances, some of clinical importance. Barbiturates and neurosteroids augment GABA-currents and also directly gate the channel. A...
8.
Gross R, Covey D, Ferrendelli J
J Pharmacol Exp Ther
. 1997 Feb;
280(2):686-94.
PMID: 9023280
Alkyl-substituted thiobutyrolactones increase or decrease gamma-aminobutyric acidA responses at or near the picrotoxin site, but they are structurally similar to ethosuximide, which prompted us to determine the actions of thiobutyrolactones...
9.
Reddy P, Woodward K, McIlheran S, Hsiang B, Latifi T, Hill M, et al.
J Med Chem
. 1997 Jan;
40(1):44-9.
PMID: 9016327
A series of 3-substituted 2-piperidinone (delta-valerolactam) and hexahydro-2H-azepin-2-one (epsilon-caprolactam) derivatives were prepared and evaluated as anticonvulsants in mice. In the 2-piperidinone series, 3,3-diethyl compound 7b is the most effective anticonvulsant...
10.
3,3-Dialkyl- and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones: a new class of anticonvulsant agents
Reddy P, Hsiang B, Latifi T, Hill M, Woodward K, Rothman S, et al.
J Med Chem
. 1996 Apr;
39(9):1898-906.
PMID: 8627613
A series of 3,3-dialkyl- and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones (lactams) have been prepared and evaluated for their anticonvulsant activities. In the pentylenetetrazole mouse seizure model, 3,3-diethyl lactam 7c and 3-benzyl-3-ethyl lactam 7j...