J A Ferrendelli
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Explore the profile of J A Ferrendelli including associated specialties, affiliations and a list of published articles.
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Articles
135
Citations
974
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Recent Articles
11.
Mathews G, Covey D, Rothman S, Ferrendelli J
Neuropharmacology
. 1996 Feb;
35(2):123-36.
PMID: 8734480
The GABAA receptor/chloride ionophore (GABAR) is allosterically modulated by several classes of anticonvulsant agents, including benzodiazepines and barbiturates, and some alkyl-substituted butyrolactones. To test the hypothesis that the anticonvulsant butyrolactones...
12.
13.
Holland K, Mathews G, Tucker J, Reddy P, Covey D, Ferrendelli J, et al.
Mol Pharmacol
. 1995 Jun;
47(6):1217-23.
PMID: 7603463
Alkyl-substituted gamma-butyrolactones (GBLs) and gamma-thiobutyrolactones exhibit convulsant or anticonvulsant activity, depending on the alkyl substituents. alpha-Substituted lactones with small alkyl substituents are anticonvulsant and potentiate gamma-aminobutyric acid (GABA)-mediated chloride currents,...
14.
Ferrendelli J
Neurology
. 1995 Mar;
45(3 Suppl 2):S12-6.
PMID: 7898740
Many patients with epilepsy can be successfully treated with a single antiepileptic drug (monotherapy). However, in a substantial number of patients, monotherapy does not provide satisfactory seizure control, and the...
15.
Ferrendelli J
Epilepsia
. 1995 Jan;
36 Suppl 2:S115-8.
PMID: 8784220
The medical treatment of seizure disorders is a complex process, requiring extensive interaction and co-operation between physician and patient. The physician must have an accurate diagnosis of the patient's illness...
16.
Mathews G, Holland K, Isenberg K, Covey D, Ferrendelli J, Rothman S
Neuron
. 1994 Jul;
13(1):149-58.
PMID: 8043274
Although we now have extensive knowledge about the GABAA receptor subunits determining benzodiazepine modulation of channel function, little is known about subunits influencing other modulatory sites on the GABAA receptor-chloride...
17.
Peterson E, Xu K, Holland K, McKeon A, Rothman S, Ferrendelli J, et al.
J Med Chem
. 1994 Jan;
37(2):275-86.
PMID: 8295215
To further study the putative gamma-butyrolactone site of the GABAA/chloride channel complex, constrained derivatives of convulsant and anticonvulsant alpha,alpha-disubstituted gamma-butyrolactones (alpha-spirocyclopropyl- and alpha-spirocyclopentyl-gamma-butyrolactones) were synthesized and evaluated biologically. Most of...
18.
Holland K, Bouley M, Covey D, Ferrendelli J
Brain Res
. 1993 Jun;
615(1):170-4.
PMID: 8395954
Effects of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones on [35S]t-butylbicyclophosphorothionate (35S-TBPS) dissociation from the picrotoxinin receptor were studied. Unlike picrotoxinin, these lactones accelerated the dissociation rate of 35S-TBPS. Thus, previous reports that...
19.
Holland K, McKeon A, Canney D, Covey D, Ferrendelli J
Epilepsia
. 1992 Nov;
33(6):981-6.
PMID: 1334454
Anticonvulsant properties of compounds that enhance GABA-mediated inhibition through modulatory sites on the GABAA receptor [phenobarbital (PB), clonazepam (CZP), alpha-ethyl-alpha-methyl-gamma-thiobutyrolactone (alpha-EMTBL)] were compared with anticonvulsant effects of compounds believed to...
20.
Canney D, Holland K, Levine J, McKeon A, Ferrendelli J, Covey D
J Med Chem
. 1991 Apr;
34(4):1460-7.
PMID: 1849999
A series of gamma-butyrolactones and gamma-thiobutyrolactones possessing a variety of alkyl groups and alkyl-substitution patterns was prepared and evaluated for anticonvulsant and convulsant activity. Behavioral studies performed on these compounds...