J A Agundez
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Explore the profile of J A Agundez including associated specialties, affiliations and a list of published articles.
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46
Citations
461
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Recent Articles
1.
Perez-Alzate D, Cornejo-Garcia J, Perez-Sanchez N, Andreu I, Garcia-Moral A, Agundez J, et al.
J Investig Allergol Clin Immunol
. 2017 Feb;
27(1):32-39.
PMID: 28211343
Background And Objectives: Individuals who develop drug hypersensitivity reactions (DHRs) to chemically unrelated nonsteroidal anti-inflammatory drugs (NSAIDs) are considered cross-hypersensitive. The hallmark for this classification is that the patient presents...
2.
Cornejo-Garcia J, Jurado-Escobar R, Dona I, Perkins J, Agundez J, Garcia-Martin E, et al.
J Investig Allergol Clin Immunol
. 2016 Jul;
26(4):222-32, quiz next two pages.
PMID: 27375032
DHRs are induced by various mechanisms and encompass a heterogeneous set of potentially life-threatening clinical entities. In addition to environmental effects, individual factors play a key role in this intricate...
3.
Blanca-Lopez N, Perez-Alzate D, Andreu I, Dona I, Agundez J, Garcia-Martin E, et al.
Allergy
. 2016 Feb;
71(7):1048-56.
PMID: 26841325
Background: Although ibuprofen and other arylpropionic acid derivatives (APs) are the most common medicines involved in hypersensitivity drug reactions (HDRs) to NSAIDs, no patient series studies have been performed regarding...
4.
Ortega-Cubero S, Lorenzo-Betancor O, Lorenzo E, Alonso E, Coria F, Pastor M, et al.
Neurobiol Aging
. 2013 Jun;
34(10):2441.e9-2441.e11.
PMID: 23731953
FUS/TLS (denoting fused in sarcoma/translocated in liposarcoma [MIM 137070]) codifies an RNA binding protein. Mutations in this gene cause amyotrophic lateral sclerosis (ALS; MIM 608030). Essential tremor (ET [MIM 190300])...
5.
Taja-Chayeb L, Agundez J, Miguez-Munoz C, Chavez-Blanco A, Duenas-Gonzalez A
Genet Mol Res
. 2012 May;
11(2):1082-92.
PMID: 22614277
The acetylating activity of N-acetyltransferase 2 (NAT2) has critical implications for therapeutics and disease susceptibility. To date, several polymorphisms that alter the enzymatic activity and/or protein stability of NAT2 have...
6.
Leiro-Fernandez V, Valverde D, Vazquez-Gallardo R, Botana-Rial M, Constenla L, Agundez J, et al.
Int J Tuberc Lung Dis
. 2012 Jan;
15(10):1403-8.
PMID: 22283902
Objective: To analyse slow-acetylation N-acetyltransferase 2 (NAT2) polymorphisms for their association with the risk of anti-tuberculosis drug-induced hepatotoxicity (ATDH). Design: A case-control study including Caucasian patients with tuberculosis (TB) treated...
7.
Dona I, Blanca-Lopez N, Cornejo-Garcia J, Torres M, Laguna J, Fernandez J, et al.
Clin Exp Allergy
. 2010 Dec;
41(1):86-95.
PMID: 21155908
Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently involved groups of medicines in hypersensitivity drug reactions. Two mechanisms can induce the reaction: immunological (sensitization) due to a...
8.
Agundez J, Gallardo L, Ledesma M, Lozano L, Rodriguez-Lescure A, Pontes J, et al.
Oncology
. 2001 Jul;
61(1):59-63.
PMID: 11474250
The cytochrome P450 CYP2D6 is a polymorphic drug-metabolizing enzyme that is involved in the metabolism of several drugs and xenobiotics. Several independent studies indicate that the CYP2D6 metabolic status is...
9.
Martinez C, Garcia-Martin E, Ladero J, Sastre J, Diaz-Rubio M, Agundez J
Carcinogenesis
. 2001 Jul;
22(8):1323-6.
PMID: 11470765
CYP2C9 enzyme activity is involved in the metabolism of substances related to colorectal cancer, and it is functionally linked to a genetic polymorphism. Two allelic variants of the CYP2C9 gene,...
10.
Garcia-Martin E, Martinez C, Ladero J, Gamito F, Agundez J
Eur J Clin Pharmacol
. 2001 May;
57(1):47-9.
PMID: 11372590
Objective: To search for ethnic variability in the impact of cytochrome P450 2C9 (CYP2C9) polymorphism. Methods: CYP2C9 allelic variants related to impaired CYP2C9 metabolism were analysed in genomic DNA from...