Ivan Trus
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Explore the profile of Ivan Trus including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
314
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Recent Articles
1.
Wolczyk M, Szymanski J, Trus I, Naz Z, Tame T, Bolembach A, et al.
Nucleic Acids Res
. 2024 Dec;
53(3).
PMID: 39704128
In vitro transcription (IVT) is a technology of vital importance that facilitated the production of mRNA therapeutics and drove numerous breakthroughs in RNA biology. T7 polymerase-produced RNAs can begin with...
2.
Le N, Singh P, Sabir A, Trus I, Karniychuk U
Virol J
. 2024 Nov;
21(1):285.
PMID: 39522048
The zinc finger antiviral protein 1 (ZAP) has broad antiviral activity. ZAP is an interferon (IFN)-stimulated gene, which itself may enhance type I IFN antiviral response. In a previous study,...
3.
Van Reeth K, Parys A, Gracia J, Trus I, Chiers K, Meade P, et al.
Nat Commun
. 2023 Nov;
14(1):7745.
PMID: 38008801
Vaccines that protect against any H1N1 influenza A virus strain would be advantageous for use in pigs and humans. Here, we try to induce a pan-H1N1 antibody response in pigs...
4.
Sabir A, Singh P, Trus I, Le N, Karniychuk U
Emerg Microbes Infect
. 2023 Sep;
12(2):2263592.
PMID: 37747060
The Zika virus 2015 epidemic showed an unusual phenotype for human flaviviruses, specifically fetal infection. We previously showed that inoculation with the Asian Zika virus isolated from the human sample...
5.
Udenze D, Trus I, Lipsit S, Napper S, Karniychuk U
Emerg Microbes Infect
. 2022 Nov;
12(1):2147021.
PMID: 36369716
Congenital virus infections, for example cytomegalovirus and rubella virus infections, commonly affect the central nervous and hematological systems in fetuses and offspring. However, interactions between emerging congenital Zika virus and...
6.
Udenze D, Trus I, Berube N, Karniychuk U
Front Immunol
. 2022 Aug;
13:943481.
PMID: 35983032
Increasing the number of CpG dinucleotides in RNA viral genomes, while preserving the original amino acid composition, leads to impaired infection which does not cause disease. Beneficially, impaired infection evokes...
7.
Choudhury N, Trus I, Heikel G, Wolczyk M, Szymanski J, Bolembach A, et al.
Nucleic Acids Res
. 2022 Jun;
50(12):7097-7114.
PMID: 35736141
The E3 ubiquitin ligase TRIM25 is a key factor in the innate immune response to RNA viruses. TRIM25 has been shown to play a role in the retinoic-acid-inducible gene-1 (RIG-I)...
8.
Trus I, Udenze D, Karniychuk U
Methods Mol Biol
. 2021 Dec;
2410:289-302.
PMID: 34914053
Experimental increase of cytosine-phosphate-guanine (CpG) dinucleotides in an RNA virus genome impairs infection. Beneficially, this weak infection may lead to robust antiviral host immunity providing a cutting-edge approach for vaccines....
9.
Udenze D, Trus I, Munyanduki H, Berube N, Karniychuk U
Viruses
. 2021 Sep;
13(9).
PMID: 34578408
The host's immune status may affect virus evolution. Little is known about how developing fetal and placental immune milieus affect virus heterogeneity. This knowledge will help us better understand intra-host...
10.
Xie J, Vereecke N, Theuns S, Oh D, Vanderheijden N, Trus I, et al.
Vaccines (Basel)
. 2021 Jul;
9(6).
PMID: 34205087
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) has a highly restricted cellular tropism. In vivo, the virus primarily infects tissue-specific macrophages in the nose, lungs, tonsils, and pharyngeal lymphoid tissues....