Ivan Cheng-Sanchez
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Explore the profile of Ivan Cheng-Sanchez including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
78
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Recent Articles
1.
Moya-Utrera F, Cheng-Sanchez I, Fuentes-Pino I, Sanchez-Ruiz A, Sarabia F
Mar Drugs
. 2025 Feb;
23(2).
PMID: 39997175
A novel class of chiral sulfonium salts, derived from L- and D-methionine, was designed and successfully employed for the diastereoselective synthesis of epoxy amides. This new methodology of asymmetric epoxidation...
2.
Palaferri L, Cheng-Sanchez I, Gossele K, Zielinska D, Nevado C
ACS Med Chem Lett
. 2025 Feb;
16(2):234-240.
PMID: 39967636
Bromodomain adjacent to zinc finger 2A and 2B (BAZ2A and BAZ2B) are homologous proteins that serve as regulatory subunits in different initiation switch complexes. Despite their structural similarity, BAZ2A/B seem...
3.
Cheng-Sanchez I, Gossele K, Palaferri L, Laul E, Riccabella G, Bedi R, et al.
JACS Au
. 2024 Sep;
4(9):3466-3474.
PMID: 39328757
We present the development of , a structurally novel PROTAC targeting the CREB-binding protein (CBP) and E1A-associated protein (EP300)-two homologous multidomain enzymes crucial for enhancer-mediated transcription. The design of was...
4.
Moya-Utrera F, Fuentes-Rios D, Romero-Carrasco A, Dona-Flores M, Cheng-Sanchez I, Diaz-Morilla A, et al.
Chemistry
. 2024 Sep;
30(70):e202402496.
PMID: 39307687
Cannabidiol (CBD) is garnering increasing interest due to its significant biological activity. This natural compound is one of the major cannabinoids in Cannabis sativa L. In this work, we describe...
5.
Hu X, Cheng-Sanchez I, Kong W, Molander G, Nevado C
Nat Catal
. 2024 Jul;
7(6):655-665.
PMID: 38947227
The development of novel strategies to rapidly construct complex chiral molecules from readily available feedstocks is a long-term pursuit in the chemistry community. Radical-mediated alkene difunctionalizations represent an excellent platform...
6.
Cheng-Sanchez I, Gossele K, Palaferri L, Kirillova M, Nevado C
ACS Med Chem Lett
. 2024 Mar;
15(3):355-361.
PMID: 38505842
Proteolysis Targeting Chimeras (PROTACs) are bifunctional molecules that simultaneously bind an E3 ligase and a protein of interest, inducing degradation of the latter via the ubiquitin-proteasome system. Here we present...
7.
Du X, Cheng-Sanchez I, Nevado C
J Am Chem Soc
. 2023 May;
145(23):12532-12540.
PMID: 37249908
An asymmetric three-component carbosulfonylation of alkenes is presented here. The reaction, involving the simultaneous formation of a C-C and a C-S bond across the π-system, uses a dual nickel/photoredox catalytic...
8.
Hu X, Cheng-Sanchez I, Cuesta-Galisteo S, Nevado C
J Am Chem Soc
. 2023 Mar;
145(11):6270-6279.
PMID: 36881734
An electrochemically driven nickel-catalyzed enantioselective reductive cross-coupling of aryl aziridines with alkenyl bromides has been developed, affording enantioenriched β-aryl homoallylic amines with excellent -selectivity. This electroreductive strategy proceeds in the...
9.
Torres-Vargas J, Cheng-Sanchez I, Martinez-Poveda B, Medina M, Sarabia F, Garcia-Caballero M, et al.
Biomed Pharmacother
. 2022 Oct;
155:113759.
PMID: 36271548
The inhibition of sustained angiogenesis is an attractive approach for the treatment of cancer, blindness and other angiogenesis-dependent diseases. Encouraged by our previous finding that toluquinol, a methyl hydroquinone isolated...
10.
Cheng-Sanchez I, Moya-Utrera F, Porras-Alcala C, Lopez-Romero J, Sarabia F
Mar Drugs
. 2022 Aug;
20(8).
PMID: 36005497
Antibody-drug conjugates (ADCs) are an important class of therapeutics for the treatment of cancer. Structurally, an ADC comprises an antibody, which serves as the delivery system, a payload drug that...