Itai Dov Tkacz
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Explore the profile of Itai Dov Tkacz including associated specialties, affiliations and a list of published articles.
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11
Citations
272
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Recent Articles
1.
Eliaz D, Kannan S, Shaked H, Arvatz G, Tkacz I, Binder L, et al.
PLoS Pathog
. 2017 Mar;
13(3):e1006245.
PMID: 28257521
Extracellular vesicles (EV) secreted by pathogens function in a variety of biological processes. Here, we demonstrate that in the protozoan parasite Trypanosoma brucei, exosome secretion is induced by stress that...
2.
Eliaz D, Doniger T, Tkacz I, Biswas V, Gupta S, Kolev N, et al.
RNA Biol
. 2015 May;
12(11):1222-55.
PMID: 25970223
Trypanosomatids are protozoan parasites and the causative agent of infamous infectious diseases. These organisms regulate their gene expression mainly at the post-transcriptional level and possess characteristic RNA processing mechanisms. In...
3.
Gupta S, Chikne V, Eliaz D, Tkacz I, Naboishchikov I, Carmi S, et al.
RNA Biol
. 2014 Jun;
11(6):715-31.
PMID: 24922194
In trypanosomes, mRNAs are processed by trans-splicing; in this process, a common exon, the spliced leader, is added to all mRNAs from a small RNA donor, the spliced leader RNA...
4.
Gupta S, Kosti I, Plaut G, Pivko A, Tkacz I, Cohen-Chalamish S, et al.
Nucleic Acids Res
. 2013 May;
41(13):6577-94.
PMID: 23666624
Trypanosomes are protozoan parasites that cycle between a mammalian host (bloodstream form) and an insect host, the Tsetse fly (procyclic stage). In trypanosomes, all mRNAs are trans-spliced as part of...
5.
Gupta S, Carmi S, Waldman Ben-Asher H, Tkacz I, Naboishchikov I, Michaeli S
J Biol Chem
. 2013 Jan;
288(7):4991-5006.
PMID: 23283975
Gene expression in trypanosomes is mainly regulated post-transcriptionally. Genes are transcribed as polycistronic mRNAs that are dissected by the concerted action of trans-splicing and polyadenylation. In trans-splicing, a common exon,...
6.
Jae N, Preusser C, Kruger T, Tkacz I, Engstler M, Michaeli S, et al.
RNA Biol
. 2011 Feb;
8(1):90-100.
PMID: 21282982
Pre-mRNA splicing in trypanosomes requires the SMN-mediated assembly of small nuclear ribonucleoproteins (snRNPs). In contrast to higher eukaryotes, the cellular localization of snRNP biogenesis and the involvement of nuclear-cytoplasmic trafficking...
7.
Tkacz I, Gupta S, Volkov V, Romano M, Haham T, Tulinski P, et al.
J Biol Chem
. 2010 Jul;
285(36):27982-99.
PMID: 20592024
In trypanosomatids, all mRNAs are processed via trans-splicing, although cis-splicing also occurs. In trans-splicing, a common small exon, the spliced leader (SL), which is derived from a small SL RNA...
8.
Hury A, Goldshmidt H, Tkacz I, Michaeli S
Eukaryot Cell
. 2008 Nov;
8(1):56-68.
PMID: 19028994
Spliced-leader-associated RNA (SLA1) guides the pseudouridylation at position -12 (relative to the 5' splice site) of the spliced-leader (SL) RNA in all trypanosomatid species. Nevertheless, the exact role of this...
9.
Tkacz I, Cohen S, Salmon-Divon M, Michaeli S
Mol Biochem Parasitol
. 2008 Apr;
160(1):22-31.
PMID: 18433897
Lsm proteins are ubiquitous, multifunctional proteins that are involved in nuclear processing and turnover of many RNAs in eukaryotes. Lsm proteins form two distinct complexes, the Lsm2-8 complex, which binds...
10.
Barth S, Shalem B, Hury A, Tkacz I, Liang X, Uliel S, et al.
Eukaryot Cell
. 2007 Nov;
7(1):86-101.
PMID: 17981991
Most eukaryotic C/D small nucleolar RNAs (snoRNAs) guide 2'-O methylation (Nm) on rRNA and are also involved in rRNA processing. The four core proteins that bind C/D snoRNA in Trypanosoma...