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Isin Geren

Explore the profile of Isin Geren including associated specialties, affiliations and a list of published articles. Areas
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Articles 2
Citations 110
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Recent Articles
1.
Fischer A, Garcia-Rodriguez C, Geren I, Lou J, Marks J, Nakagawa T, et al.
J Biol Chem . 2007 Nov; 283(7):3997-4003. PMID: 18032388
Clostridial botulinum neurotoxin (BoNT) causes a neuroparalytic condition recognized as botulism by arresting synaptic vesicle exocytosis. Although the crystal structures of full-length BoNT/A and BoNT/B holotoxins are known, the molecular...
2.
Garcia-Rodriguez C, Levy R, Arndt J, Forsyth C, Razai A, Lou J, et al.
Nat Biotechnol . 2006 Dec; 25(1):107-16. PMID: 17173035
Broadening antibody specificity without compromising affinity should facilitate detection and neutralization of toxin and viral subtypes. We used yeast display and a co-selection strategy to increase cross-reactivity of a single...