Consuelo Garcia-Rodriguez
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Explore the profile of Consuelo Garcia-Rodriguez including associated specialties, affiliations and a list of published articles.
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14
Citations
321
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Recent Articles
1.
Fan Y, Lou J, Tam C, Wen W, Conrad F, Leal da Silva Alves P, et al.
Toxins (Basel)
. 2023 May;
15(5).
PMID: 37235351
Equine-derived antitoxin (BAT) is the only treatment for botulism from botulinum neurotoxin serotype G (BoNT/G). BAT is a foreign protein with potentially severe adverse effects and is not renewable. To...
2.
Garcia-Rodriguez C, Yan S, Geren I, Knopp K, Dong J, Sun Z, et al.
Toxins (Basel)
. 2021 Sep;
13(9).
PMID: 34564645
Human botulism can be caused by botulinum neurotoxin (BoNT) serotypes A to G. Here, we present an antibody-based antitoxin composed of four human monoclonal antibodies (mAbs) against BoNT/C, BoNT/D, and...
3.
Snow D, Riling K, Kimbler A, Espinoza Y, Wong D, Pham K, et al.
Antimicrob Agents Chemother
. 2019 Oct;
63(12).
PMID: 31591130
Botulism is caused by botulinum neurotoxin (BoNT), the most poisonous substance known. BoNTs are also classified as Tier 1 biothreat agents due to their high potency and lethality. The existence...
4.
Garcia-Rodriguez C, Razai A, Geren I, Lou J, Conrad F, Wen W, et al.
Toxins (Basel)
. 2018 Mar;
10(3).
PMID: 29494481
Human botulism is most commonly caused by botulinum neurotoxin (BoNT) serotypes A, B, and E. For this work, we sought to develop a human monoclonal antibody (mAb)-based antitoxin capable of...
5.
Lou J, Wen W, Conrad F, Meng Q, Dong J, Sun Z, et al.
Toxins (Basel)
. 2018 Feb;
10(2).
PMID: 29462889
The standard of treatment for botulism, equine antitoxin, is a foreign protein with associated safety issues and a short serum half-life which excludes its use as a prophylactic antitoxin and...
6.
Fan Y, Garcia-Rodriguez C, Lou J, Wen W, Conrad F, Zhai W, et al.
PLoS One
. 2017 Mar;
12(3):e0174187.
PMID: 28323873
Human botulism is primarily caused by botulinum neurotoxin (BoNT) serotypes A, B and E, with around 1% caused by serotype F (BoNT/F). BoNT/F comprises at least seven different subtypes with...
7.
Fan Y, Dong J, Lou J, Wen W, Conrad F, Geren I, et al.
Toxins (Basel)
. 2015 Sep;
7(9):3405-23.
PMID: 26343720
Existing antibodies (Abs) used to treat botulism cannot enter the cytosol of neurons and bind to botulinum neurotoxin (BoNT) at its site of action, and thus cannot reverse paralysis. However,...
8.
Jenko K, Zhang Y, Kostenko Y, Fan Y, Garcia-Rodriguez C, Lou J, et al.
Analyst
. 2014 Aug;
139(20):5093-102.
PMID: 25112421
Plant and microbial toxins are considered bioterrorism threat agents because of their extreme toxicity and/or ease of availability. Additionally, some of these toxins are increasingly responsible for accidental food poisonings....
9.
Mahrhold S, Strotmeier J, Garcia-Rodriguez C, Lou J, Marks J, Rummel A, et al.
Biochem J
. 2013 Apr;
453(1):37-47.
PMID: 23621114
The highly specific binding and uptake of BoNTs (botulinum neurotoxins; A-G) into peripheral cholinergic motoneurons turns them into the most poisonous substances known. Interaction with gangliosides accumulates the neurotoxins on...
10.
Kalb S, Santana W, Geren I, Garcia-Rodriguez C, Lou J, Smith T, et al.
BMC Biochem
. 2011 Nov;
12:58.
PMID: 22085466
Background: Botulism is caused by botulinum neurotoxins (BoNTs), extremely toxic proteins which can induce respiratory failure leading to long-term intensive care or death. Treatment for botulism includes administration of antitoxins,...