Ishan Manandhar
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Explore the profile of Ishan Manandhar including associated specialties, affiliations and a list of published articles.
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14
Citations
354
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Recent Articles
1.
Mandal J, Aryal S, Manandhar I, Chakraborty S, Mei X, Yeoh B, et al.
bioRxiv
. 2025 Jan;
PMID: 39763881
Starvation, intermittent fasting and exercise, all of which are recommended lifestyle modifiers share a common metabolic signature, ketogenesis to generate the ketone bodies, predominantly β-hydroxybutyrate. β-hydroxybutyrate exerts beneficial effects across...
2.
Bardhan P, Mei X, Lai N, Mell B, Tummala R, Aryal S, et al.
Circ Res
. 2024 Oct;
135(12):1122-1137.
PMID: 39440438
Background: Tryptophan metabolism is important in blood pressure regulation. The tryptophan-indole pathway is exclusively mediated by the gut microbiota. ACE2 (angiotensin-converting enzyme 2) participates in tryptophan absorption, and a lack...
3.
Durgan D, Zubcevic J, Vijay-Kumar M, Yang T, Manandhar I, Aryal S, et al.
Hypertension
. 2024 Apr;
81(5):951-963.
PMID: 38630799
No abstract available.
4.
Aryal S, Manandhar I, Mei X, Yeoh B, Tummala R, Saha P, et al.
Camb Prism Precis Med
. 2024 Mar;
1:e26.
PMID: 38550938
The single largest contributor to human mortality is cardiovascular disease, the top risk factor for which is hypertension (HTN). The last two decades have placed much emphasis on the identification...
5.
Mei X, Mell B, Aryal S, Manandhar I, Tummala R, Zubcevic J, et al.
Pharmacol Res
. 2023 Sep;
196:106920.
PMID: 37716548
Engineered gut microbiota represents a new frontier in medicine, in part serving as a vehicle for the delivery of therapeutic biologics to treat a range of host conditions. The gut...
6.
Du Toit C, Tran T, Deo N, Aryal S, Lip S, Sykes R, et al.
J Am Heart Assoc
. 2023 Apr;
12(9):e027896.
PMID: 37119074
Background Machine learning (ML) is pervasive in all fields of research, from automating tasks to complex decision-making. However, applications in different specialities are variable and generally limited. Like other conditions,...
7.
Mei X, Mell B, Manandhar I, Aryal S, Tummala R, Kyoung J, et al.
J Am Heart Assoc
. 2022 Dec;
11(24):e027893.
PMID: 36533597
Background The gut and gut microbiota, which were previously neglected in blood pressure regulation, are becoming increasingly recognized as factors contributing to hypertension. Diseases affecting the gut such as inflammatory...
8.
Li H, Xu M, Xu X, Tang Y, Jiang H, Li L, et al.
Circ Res
. 2022 Sep;
131(9):e120-e134.
PMID: 36164984
Background: Despite available clinical management strategies, chronic kidney disease (CKD) is associated with severe morbidity and mortality worldwide, which beckons new solutions. Host-microbial interactions with a depletion of in CKD...
9.
Cheng X, Manandhar I, Aryal S, Joe B
Compr Physiol
. 2021 Sep;
11(4):2455-2466.
PMID: 34558666
The advent of advances in machine learning (ML)-based techniques has popularized wide applications of artificial intelligence (AI) in various fields ranging from robotics to medicine. In recent years, there has...
10.
Manandhar I, Alimadadi A, Aryal S, Munroe P, Joe B, Cheng X
Am J Physiol Gastrointest Liver Physiol
. 2021 Jan;
320(3):G328-G337.
PMID: 33439104
Despite the availability of various diagnostic tests for inflammatory bowel diseases (IBD), misdiagnosis of IBD occurs frequently, and thus, there is a clinical need to further improve the diagnosis of...