Isao Shimizu
Overview
Explore the profile of Isao Shimizu including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
653
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Recent Articles
1.
Kitaichi M, Kato T, Oki H, Tatara A, Kawada T, Miyazaki K, et al.
Psychopharmacology (Berl)
. 2024 Jun;
241(11):2223-2239.
PMID: 38856765
Background: Current treatment of major depressive disorder is facing challenges, including a low remission rate, late onset of efficacy, and worsening severity due to comorbid symptoms such as psychosis and...
2.
Ieguchi K, Tomita T, Takao T, Omori T, Mishima T, Shimizu I, et al.
Int J Mol Sci
. 2021 Apr;
22(5).
PMID: 33804570
Accumulating evidence indicates that an elevated ephrin-A1 expression is positively correlated with a worse prognosis in some cancers such as colon and liver cancer. The detailed mechanism of an elevated...
3.
Haraguchi S, Kamata M, Tokita T, Tashiro K, Sato M, Nozaki M, et al.
Elife
. 2019 Oct;
8.
PMID: 31566568
The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity...
4.
Hashimoto T, Baba S, Ikeda H, Oda Y, Hashimoto K, Shimizu I
Eur J Pharmacol
. 2018 Apr;
830:26-32.
PMID: 29684390
Long-term treatment with antipsychotic drugs in patients with schizophrenia can lead to dopamine supersensitivity psychosis. It is reported that repeated administration of haloperidol caused dopamine supersensitivity in rats. Blonanserin is...
5.
Tsubouchi T, Kunimatsu T, Tsujimoto S, Kiyoshi A, Katsura Y, Oku S, et al.
Eur J Pharmacol
. 2018 Mar;
826:96-105.
PMID: 29501863
The pharmacological activity of DSP-6952, a novel compound was investigated, compared to that of clinically efficacious gastrointestinal (GI) prokinetic 5-hydroxytryptamine (5-HT) receptor agonists. DSP-6952 had a strong affinity of Ki ...
6.
Mine Y, Itakura T, Oku S, Asada R, Shimizu I
Eur J Pharmacol
. 2018 Feb;
826:123-132.
PMID: 29428470
The pharmacological profile of DSP-6952, a novel 5-HT receptor partial agonist, was investigated to evaluate the potential use for GI disorders, and to compare its effects in some GI dysfunction...
7.
Okamoto M, Naka K, Ishiwata K, Shimizu I, Toyohara J
Ann Nucl Med
. 2016 Sep;
31(1):53-62.
PMID: 27680022
Objective: 7α-Substituted androgen derivatives may have the potential to visualize androgen receptors with positron emission tomography. In the present study, we synthesized fluoropropyl derivatives of 7α-(3-[F]fluoropropyl)-testosterone ([F]7) and 7α-(3-[F]fluoropropyl)-dihydrotestosterone ([F]15),...
8.
Shimura M, Shindou H, Szyrwiel L, Tokuoka S, Hamano F, Matsuyama S, et al.
FASEB J
. 2016 Sep;
30(12):4149-4158.
PMID: 27601443
Fatty acids are taken up by cells and incorporated into complex lipids such as neutral lipids and glycerophospholipids. Glycerophospholipids are major constituents of cellular membranes. More than 1000 molecular species...
9.
Usuda K, Biswas T, Yamaguchi T, Akagi Y, Yasui K, Uesugi M, et al.
Chem Pharm Bull (Tokyo)
. 2016 Aug;
64(8):1190-5.
PMID: 27477659
1β,3β,25-Dihydroxy-19-norvitamin D3 (4a) and 1α,3α,25-dihydroxy-19-norvitamin D3 (4b) were synthesized by employing a new A-ring synthon, (1R,3S)-3-((tert-butyldimethylsilyl)oxy)-5-oxocyclohexyl benzoate (19), which was derived from D-(-)-quinic acid in 12 steps. The A-ring was...
10.
Biswas T, Akagi Y, Usuda K, Yasui K, Shimizu I, Okamoto M, et al.
Biol Pharm Bull
. 2016 Aug;
39(8):1387-91.
PMID: 27476947
Two vitamin D3 derivatives, namely 24,24-difluoro-1β,3β,25-dihydroxy-19-norvitamin D3 (6a) and 24,24-difluoro-1α,3α,25-dihydroxy-19-norvitamin D3 (6b), were synthesized via a convergent route employing Julia-Kocienski olefination as a key step. Compounds 6a and b bound...