Light-at-night Exposure Affects Brain Development Through Pineal Allopregnanolone-dependent Mechanisms

Overview

Journal Elife

Specialty Biology

Date 2019 Oct 1

PMID 31566568

Citations 11

Authors

Shogo Haraguchi

Masaki Kamata

Takuma Tokita

Kei-Ichiro Tashiro

Miku Sato

Mitsuki Nozaki

Mayumi Okamoto-Katsuyama

Isao Shimizu

Guofeng Han

Vishwajit Sur Chowdhury

Xiao-Feng Lei

Takuro Miyazaki

Joo-Ri Kim-Kaneyama

Tomoya Nakamachi

Kouhei Matsuda

Hirokazu Ohtaki

Toshinobu Tokumoto

Tetsuya Tachibana

Akira Miyazaki

Kazuyoshi Tsutsui

Affiliations

Soon will be listed here.

Abstract

The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity during early life in chicks. Light-at-night caused the loss of diurnal variation of pineal ALLO synthesis during early life and led to cerebellar Purkinje cell death, which was suppressed by a daily injection of ALLO. The loss of diurnal variation of pineal ALLO synthesis induced not only reduction in pituitary adenylate cyclase-activating polypeptide (PACAP), a neuroprotective hormone, but also transcriptional repression of the cerebellar gene that produces PACAP, with subsequent Purkinje cell death. Taken together, pineal ALLO mediated the effect of light on early cerebellar development in chicks.

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