Isabelle Hazemann
Overview
Explore the profile of Isabelle Hazemann including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
30
Citations
575
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Holvec S, Barchet C, Lechner A, Frechin L, De Silva S, Hazemann I, et al.
Nat Struct Mol Biol
. 2024 Jun;
31(8):1251-1264.
PMID: 38844527
The ribosomal RNA of the human protein synthesis machinery comprises numerous chemical modifications that are introduced during ribosome biogenesis. Here we present the 1.9 Å resolution cryo electron microscopy structure...
2.
Barchet C, Frechin L, Holvec S, Hazemann I, von Loeffelholz O, Klaholz B
J Struct Biol
. 2023 Sep;
215(4):108015.
PMID: 37659578
Recent advances in cryo electron microscopy (cryo-EM) and image processing provide new opportunities to analyse drug targets at high resolution. However, structural heterogeneity limits resolution in many practical cases, hence...
3.
Patel A, Vilela P, Shaik T, McEwen A, Hazemann I, Brillet K, et al.
Nucleic Acids Res
. 2023 Jul;
51(16):8864-8879.
PMID: 37503845
Transcription factors, such as nuclear receptors achieve precise transcriptional regulation by means of a tight and reciprocal communication with DNA, where cooperativity gained by receptor dimerization is added to binding...
4.
Frechin L, Holvec S, von Loeffelholz O, Hazemann I, Klaholz B
J Struct Biol
. 2022 Oct;
215(1):107905.
PMID: 36241135
Recent technological advances in cryo electron microscopy (cryo-EM) have led to new opportunities in the structural biology field. Here we benchmark the performance of two 300 kV latest-generation cryo electron...
5.
Beinsteiner B, Markov G, Bourguet M, McEwen A, Erb S, Patel A, et al.
BMC Biol
. 2022 Oct;
20(1):217.
PMID: 36199108
Background: Nuclear receptors are transcription factors of central importance in human biology and associated diseases. Much of the knowledge related to their major functions, such as ligand and DNA binding...
6.
Natchiar S, Myasnikov A, Hazemann I, Klaholz B
Biomolecules
. 2018 Oct;
8(4).
PMID: 30366442
Chemical modifications of RNA have recently gained new attention in biological sciences. They occur notably on messenger RNA (mRNA) and ribosomal RNA (rRNA) and are important for various cellular functions,...
7.
von Loeffelholz O, Papai G, Danev R, Myasnikov A, Natchiar S, Hazemann I, et al.
J Struct Biol
. 2018 Jan;
202(3):191-199.
PMID: 29337113
A current bottleneck in structure determination of macromolecular complexes by cryo electron microscopy (cryo-EM) is the large amount of data needed to obtain high-resolution 3D reconstructions, including through sorting into...
8.
Natchiar S, Myasnikov A, Kratzat H, Hazemann I, Klaholz B
Nature
. 2017 Nov;
551(7681):472-477.
PMID: 29143818
Chemical modifications of human ribosomal RNA (rRNA) are introduced during biogenesis and have been implicated in the dysregulation of protein synthesis, as is found in cancer and other diseases. However,...
9.
von Loeffelholz O, Natchiar S, Djabeur N, Myasnikov A, Kratzat H, Menetret J, et al.
Curr Opin Struct Biol
. 2017 Aug;
46:140-148.
PMID: 28850874
Cryo electron microscopy (cryo-EM) historically has had a strong impact on the structural and mechanistic analysis of protein synthesis by the prokaryotic and eukaryotic ribosomes. Vice versa, studying ribosomes has...
10.
Mohideen-Abdul K, Tazibt K, Bourguet M, Hazemann I, Lebars I, Takacs M, et al.
Front Endocrinol (Lausanne)
. 2017 Jul;
8:140.
PMID: 28676789
Most nuclear receptors (NRs) bind DNA as dimers, either as hetero- or as homodimers on DNA sequences organized as two half-sites with specific orientation and spacing. The dimerization of NRs...