Alexander G Myasnikov
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Explore the profile of Alexander G Myasnikov including associated specialties, affiliations and a list of published articles.
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39
Citations
1768
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Recent Articles
1.
Panteleev P, Pichkur E, Kruglikov R, Paleskava A, Shulenina O, Bolosov I, et al.
Nat Commun
. 2024 Oct;
15(1):8925.
PMID: 39414793
The antimicrobial resistance crisis along with challenges of antimicrobial discovery revealed the vital necessity to develop new antibiotics. Many of the animal proline-rich antimicrobial peptides (PrAMPs) inhibit the process of...
2.
Nurullina L, Terrosu S, Myasnikov A, Jenner L, Yusupov M
FEBS Lett
. 2024 Feb;
598(5):537-547.
PMID: 38395592
Here, we present the high-resolution structure of the Gallus gallus 80S ribosome obtained from cold-treated chicken embryos. The translationally inactive ribosome complex contains elongation factor eEF2 with GDP, SERPINE1 mRNA...
3.
Paternoga H, Crowe-McAuliffe C, Bock L, Koller T, Morici M, Beckert B, et al.
Nat Struct Mol Biol
. 2023 Aug;
30(9):1380-1392.
PMID: 37550453
The ribosome is a major target for clinically used antibiotics, but multidrug resistant pathogenic bacteria are making our current arsenal of antimicrobials obsolete. Here we present cryo-electron-microscopy structures of 17...
4.
Holm M, Natchiar S, Rundlet E, Myasnikov A, Watson Z, Altman R, et al.
Nature
. 2023 Apr;
617(7959):200-207.
PMID: 37020024
In all species, ribosomes synthesize proteins by faithfully decoding messenger RNA (mRNA) nucleotide sequences using aminoacyl-tRNA substrates. Current knowledge of the decoding mechanism derives principally from studies on bacterial systems....
5.
Tsai K, Stojkovic V, Noda-Garcia L, Young I, Myasnikov A, Kleinman J, et al.
Elife
. 2022 Jan;
11.
PMID: 35015630
Alteration of antibiotic binding sites through modification of ribosomal RNA (rRNA) is a common form of resistance to ribosome-targeting antibiotics. The rRNA-modifying enzyme Cfr methylates an adenosine nucleotide within the...
6.
Wang R, Noddings C, Kirschke E, Myasnikov A, Johnson J, Agard D
Nature
. 2021 Dec;
601(7893):460-464.
PMID: 34937942
Maintaining a healthy proteome is fundamental for the survival of all organisms. Integral to this are Hsp90 and Hsp70, molecular chaperones that together facilitate the folding, remodelling and maturation of...
7.
Reshetnyak A, Rossi P, Myasnikov A, Sowaileh M, Mohanty J, Nourse A, et al.
Nature
. 2021 Nov;
600(7887):153-157.
PMID: 34819673
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) that regulates important functions in the central nervous system. The ALK gene is a hotspot for chromosomal translocation events that...
8.
Rundlet E, Holm M, Schacherl M, Natchiar S, Altman R, Spahn C, et al.
Nature
. 2021 Jul;
595(7869):741-745.
PMID: 34234344
Peptide-chain elongation during protein synthesis entails sequential aminoacyl-tRNA selection and translocation reactions that proceed rapidly (2-20 per second) and with a low error rate (around 10 to 10 at each...
9.
Maksimova E, Korepanov A, Kravchenko O, Baymukhametov T, Myasnikov A, Vassilenko K, et al.
Int J Mol Sci
. 2021 Jul;
22(11).
PMID: 34200244
Ribosome biogenesis is a highly coordinated and complex process that requires numerous assembly factors that ensure prompt and flawless maturation of ribosomal subunits. Despite the increasing amount of data collected,...
10.
Wang Y, Niu Y, Zhang Z, Gable K, Gupta S, Somashekarappa N, et al.
Nat Struct Mol Biol
. 2021 Feb;
28(3):240-248.
PMID: 33558761
Sphingolipids are essential lipids in eukaryotic membranes. In humans, the first and rate-limiting step of sphingolipid synthesis is catalyzed by the serine palmitoyltransferase holocomplex, which consists of catalytic components (SPTLC1...