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Isabelle Bertin

Explore the profile of Isabelle Bertin including associated specialties, affiliations and a list of published articles. Areas
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Articles 15
Citations 444
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Recent Articles
1.
Hammoud H, Elhabazi K, Quillet R, Bertin I, Utard V, Laboureyras E, et al.
ACS Chem Neurosci . 2018 May; 9(11):2599-2609. PMID: 29727163
Neuropeptide FF receptors (NPFF1R and NPFF2R) and their endogenous ligand neuropeptide FF have been shown previously to display antiopioid properties and to play a critical role in the adverse effects...
2.
Elhabazi K, Humbert J, Bertin I, Quillet R, Utard V, Schneider S, et al.
Neuropharmacology . 2017 Mar; 118:188-198. PMID: 28288815
Although opiates represent the most effective analgesics, their use in chronic treatments is associated with numerous side effects including the development of pain hypersensitivity and analgesic tolerance. We recently identified...
3.
Doebelin C, Bertin I, Schneider S, Schmitt M, Bourguignon J, Ancel C, et al.
ChemMedChem . 2016 Aug; 11(19):2147-2154. PMID: 27562608
A series of dipeptides were designed as potential agonists of the human KiSS1-derived peptide receptor (hGPR54). While the sequence Arg-Trp-NH was the most efficient in terms of affinity, we established...
4.
Roumeas L, Humbert J, Schneider S, Doebelin C, Bertin I, Schmitt M, et al.
Peptides . 2015 Jul; 71:156-61. PMID: 26211894
Mammalian RF-amide peptides including RF-amide-related peptides-1 and -3, neuropeptides AF and FF, Prolactin releasing peptides, Kisspeptins and RFa peptides are currently considered endogenous peptides for the GPCRs NPFF1R, NPFF2R, GPR10,...
5.
Portelli J, Meurs A, Bihel F, Hammoud H, Schmitt M, Kock J, et al.
Neuropharmacology . 2015 May; 95:415-23. PMID: 25963417
Neuropeptide Y (NPY) is a well established anticonvulsant and first-in-class antiepileptic neuropeptide. In this study, the controversial role of NPY1 receptors in epilepsy was reassessed by testing two highly selective...
6.
Bihel F, Humbert J, Schneider S, Bertin I, Wagner P, Schmitt M, et al.
ACS Chem Neurosci . 2015 Jan; 6(3):438-45. PMID: 25588572
Through the development of a new class of unnatural ornithine derivatives as bioisosteres of arginine, we have designed an orally active peptidomimetic antagonist of neuropeptide FF receptors (NPFFR). Systemic low-dose...
7.
Breen J, Wicker T, Shatalina M, Frenkel Z, Bertin I, Philippe R, et al.
PLoS One . 2013 Nov; 8(11):e80272. PMID: 24278269
Bread wheat (Triticum aestivum) has a large and highly repetitive genome which poses major technical challenges for its study. To aid map-based cloning and future genome sequencing projects, we constructed...
8.
Elhabazi K, Humbert J, Bertin I, Schmitt M, Bihel F, Bourguignon J, et al.
Neuropharmacology . 2013 Aug; 75:164-71. PMID: 23911743
Mammalian RF-amide peptides are encoded by five different genes and act through five different G protein-coupled receptors. RF-amide-related peptides-1 and -3, neuropeptides AF and FF, Prolactin releasing peptides, Kisspeptins and...
9.
Philippe R, Paux E, Bertin I, Sourdille P, Choulet F, Laugier C, et al.
Genome Biol . 2013 Jun; 14(6):R64. PMID: 23800011
Background: As for other major crops, achieving a complete wheat genome sequence is essential for the application of genomics to breeding new and improved varieties. To overcome the complexities of...
10.
Gealageas R, Schneider S, Humbert J, Bertin I, Schmitt M, Laboureyras E, et al.
Bioorg Med Chem Lett . 2012 Nov; 22(24):7471-4. PMID: 23131340
Based on our earlier reported neuropeptide FF receptors antagonist (RF9), we carried out an extensive structural exploration of the N-terminus part of the amidated dipeptide Arg-Phe-NH(2) in order to establish...