Isabella Palazzo
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Explore the profile of Isabella Palazzo including associated specialties, affiliations and a list of published articles.
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20
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Recent Articles
1.
Singh K, Jin Y, Hu M, Palazzo I, Cano M, Hoang T, et al.
bioRxiv
. 2025 Feb;
PMID: 39974955
Environmental exposure such as cigarette smoke induces epigenetic changes that can induce degenerative heterogeneity and accelerate aging. In early age-related macular degeneration (AMD), the leading worldwide cause of blindness among...
2.
Taylor O, El-Hodiri H, Palazzo I, Todd L, Fischer A
Glia
. 2024 Oct;
73(1):4-24.
PMID: 39448874
We summarize recent findings in different animal models regarding the different cell-signaling pathways and gene networks that influence the reprogramming of Müller glia into proliferating, neurogenic progenitor cells in the...
3.
Le N, Awad S, Palazzo I, Hoang T, Blackshaw S
bioRxiv
. 2024 Sep;
PMID: 39345433
Retinal Müller glia in cold-blooded vertebrates can reprogram into neurogenic progenitors to replace neurons lost to injury, but mammals lack this ability. While recent studies have shown that transgenic overexpression...
4.
Emmerich K, Hageter J, Hoang T, Lyu P, Sharrock A, Ceisel A, et al.
Development
. 2024 Jul;
151(15).
PMID: 39007397
Many genes are known to regulate retinal regeneration after widespread tissue damage. Conversely, genes controlling regeneration after limited cell loss, as per degenerative diseases, are undefined. As stem/progenitor cell responses...
5.
Le N, Vu T, Palazzo I, Pulya R, Kim Y, Blackshaw S, et al.
Sci Adv
. 2024 Jul;
10(28):eadn2091.
PMID: 38996013
Generation of neurons through direct reprogramming has emerged as a promising therapeutic approach for treating neurodegenerative diseases. In this study, we present an efficient method for reprogramming retinal glial cells...
6.
Lyu P, Iribarne M, Serjanov D, Zhai Y, Hoang T, Campbell L, et al.
Nat Commun
. 2023 Dec;
14(1):8477.
PMID: 38123561
Following acute retinal damage, zebrafish possess the ability to regenerate all neuronal subtypes through Müller glia (MG) reprogramming and asymmetric cell division that produces a multipotent Müller glia-derived neuronal progenitor...
7.
Emmerich K, Hageter J, Hoang T, Lyu P, Sharrock A, Ceisel A, et al.
bioRxiv
. 2023 Dec;
PMID: 38045256
One Sentence Summary: We discovered eighteen genes that regulate the regeneration of retinal ganglion cells in zebrafish.
8.
El-Hodiri H, Bentley J, Reske A, Taylor O, Palazzo I, Campbell W, et al.
Development
. 2023 Nov;
150(23).
PMID: 37971210
Recent studies have demonstrated the impact of pro-inflammatory signaling and reactive microglia/macrophages on the formation of Müller glial-derived progenitor cells (MGPCs) in the retina. In chick retina, ablation of microglia/macrophages...
9.
Le N, Vu T, Palazzo I, Pulya R, Kim Y, Blackshaw S, et al.
bioRxiv
. 2023 Nov;
PMID: 37961663
Generation of neurons through direct reprogramming has emerged as a promising therapeutic approach for neurodegenerative diseases. Despite successful applications , implementation has been hampered by low efficiency. In this study,...
10.
Blackshaw S, Lyu P, Zhai Y, Qian J, Iribarne M, Serjanov D, et al.
Res Sq
. 2023 Oct;
PMID: 37790324
Following acute retinal damage, zebrafish possess the ability to regenerate all neuronal subtypes. This regeneration requires Müller glia (MG) to reprogram and divide asymmetrically to produce a multipotent Müller glia-derived...