Isabel Frahm
Overview
Explore the profile of Isabel Frahm including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
545
Followers
0
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Recent Articles
1.
El Bairi K, Haynes H, Blackley E, Fineberg S, Shear J, Turner S, et al.
NPJ Breast Cancer
. 2021 Dec;
7(1):150.
PMID: 34853355
The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes...
2.
Gonzalez-Ericsson P, Stovgaard E, Sua L, Reisenbichler E, Kos Z, Carter J, et al.
J Pathol
. 2020 Mar;
250(5):667-684.
PMID: 32129476
Immune checkpoint inhibitor therapies targeting PD-1/PD-L1 are now the standard of care in oncology across several hematologic and solid tumor types, including triple negative breast cancer (TNBC). Patients with metastatic...
3.
Mercogliano M, Inurrigarro G, De Martino M, Venturutti L, Rivas M, Cordo-Russo R, et al.
BMC Cancer
. 2017 Dec;
17(1):895.
PMID: 29281999
Background: Invasive micropapillary carcinoma of the breast (IMPC) is a histological tumor variant that occurs with low frequency characterized by an inside-out formation of tumor clusters with a pseudopapillary arrangement....
4.
Mercogliano M, De Martino M, Venturutti L, Rivas M, Proietti C, Inurrigarro G, et al.
Clin Cancer Res
. 2016 Oct;
23(3):636-648.
PMID: 27698002
Purpose: Although trastuzumab administration improved the outcome of HER2-positive breast cancer patients, resistance events hamper its clinical benefits. We demonstrated that TNFα stimulation in vitro induces trastuzumab resistance in HER2-positive...
5.
Weinberg R, Grecco M, Ferro G, Seigelshifer D, Perroni N, Terrier F, et al.
Springerplus
. 2015 Aug;
4:428.
PMID: 26306290
Desmopressin (dDAVP) is a well-known peptide analog of the antidiuretic hormone vasopressin, used to prevent excessive bleeding during surgical procedures. dDAVP increases hemostatic mediators, such as the von Willebrand factor...
6.
Tkach M, Coria L, Rosemblit C, Rivas M, Proietti C, Diaz Flaque M, et al.
J Immunol
. 2012 Jul;
189(3):1162-72.
PMID: 22753933
Aberrant Stat3 activation and signaling contribute to malignant transformation by promoting cell cycle progression, inhibiting apoptosis, and mediating tumor immune evasion. Stat3 inhibition in tumor cells induces the expression of...
7.
Schillaci R, Guzman P, Cayrol F, Beguelin W, Diaz Flaque M, Proietti C, et al.
BMC Cancer
. 2012 Feb;
12:74.
PMID: 22356700
Background: The biological relevance of nuclear ErbB-2/HER2 (NuclErbB-2) presence in breast tumors remains unexplored. In this study we assessed the clinical significance of ErbB-2 nuclear localization in primary invasive breast...
8.
Pena D, Pontillo C, Garcia M, Cocca C, Alvarez L, Chiappini F, et al.
Toxicology
. 2012 Jan;
293(1-3):68-77.
PMID: 22245120
Hexachlorobenzene (HCB) is an organochlorine pesticide that acts as an endocrine disruptor in humans and rodents. The development of breast cancer strongly depends on endocrine conditions modulated by environmental factors....
9.
Cardenas Delgado V, Nugnes L, Colombo L, Troncoso M, Fernandez M, Malchiodi E, et al.
FASEB J
. 2010 Sep;
25(1):242-54.
PMID: 20876211
Angiogenesis, the growth of new capillaries from preexisting blood vessels, is a complex process involving endothelial cell (EC) activation, disruption of vascular basement membranes, and migration and proliferation of ECs....
10.
Rivas M, Carnevale R, Proietti C, Rosemblit C, Beguelin W, Salatino M, et al.
Exp Cell Res
. 2007 Dec;
314(3):509-29.
PMID: 18061162
Tumor necrosis factor alpha (TNF alpha) enhances proliferation of chemically-induced mammary tumors and of T47D human cell line through not fully understood pathways. Here, we explored the intracellular signaling pathways...