Isabel Devesa
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Explore the profile of Isabel Devesa including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
1054
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Recent Articles
1.
Devesa I, Fernandez-Ballester G, Fernandez-Carvajal A, Ferrer-Montiel A
Expert Opin Ther Pat
. 2025 Feb;
:1-15.
PMID: 39952645
Introduction: TRPV1, a pivotal therapeutic target for chronic pain and pruritus, has been validated in the pathogenesis of several pathologies from diabetes to cancer. Despite the constellation of chemical structures...
2.
Nikolaeva-Koleva M, Espinosa A, Vergassola M, Polenzani L, Mangano G, Ragni L, et al.
Mol Pain
. 2023 Sep;
19:17448069231204191.
PMID: 37710969
Benzydamine is an active pharmaceutical compound used in the oral care pharmaceutical preparation as NSAID. Beside from its anti-inflammatory action, benzydamine local application effectively reliefs pain showing analgesic and anaesthetic...
3.
Butron L, Nikolaeva-Koleva M, Sempere A, Rivero V, Fernandez-Ballester G, Espinosa A, et al.
Exp Dermatol
. 2023 Apr;
32(7):999-1006.
PMID: 37009806
Thermoregulation and heat dissipation by sweat production and evaporation are vital for human survival. However, hyperhidrosis or excessive perspiration might affect people's quality of life by causing discomfort and stress....
4.
Butron D, Zamora-Carreras H, Devesa I, Trevino M, Abian O, Velazquez-Campoy A, et al.
Bioorg Chem
. 2021 Aug;
115:105231.
PMID: 34388485
The analgesic peptide DD04107 (Pal-EEMQRR-NH) and its acetylated analogue inhibit α-calcitonin gene-related peptide (α-CGRP) exocytotic release from primary sensory neurons. Examining the crystal structure of the SNARE-Synaptotagmin-1(Syt1) complex, we hypothesized...
5.
Nikolaeva-Koleva M, Butron L, Gonzalez-Rodriguez S, Devesa I, Valente P, Serafini M, et al.
Sci Rep
. 2021 Jan;
11(1):246.
PMID: 33420359
TRPV1, a member of the transient receptor potential (TRP) family, is a nonselective calcium permeable ion channel gated by physical and chemical stimuli. In the skin, TRPV1 plays an important...
6.
Gonzalez-Gil I, Zian D, Vazquez-Villa H, Hernandez-Torres G, Martinez R, Khiar-Fernandez N, et al.
J Med Chem
. 2019 Dec;
63(5):2372-2390.
PMID: 31790581
Neuropathic pain (NP) is a complex chronic pain state with a prevalence of almost 10% in the general population. Pharmacological options for NP are limited and weakly effective, so there...
7.
Serafini M, Griglio A, Aprile S, Seiti F, Travelli C, Pattarino F, et al.
J Med Chem
. 2018 May;
61(10):4436-4455.
PMID: 29722529
Despite being an old molecule, capsaicin is still a hot topic in the scientific community, and the development of new capsaicinoids is a promising pharmacological approach in the management of...
8.
Mathivanan S, Devesa I, Changeux J, Ferrer-Montiel A
Front Pharmacol
. 2016 Jul;
7:178.
PMID: 27445816
Transient receptor potential vanilloid I (TRPV1) sensitization in peripheral nociceptors is a prominent phenomenon that occurs in inflammatory pain conditions. Pro-algesic agents can potentiate TRPV1 activity in nociceptors through both...
9.
Taberner F, Devesa I, Ferrer-Montiel A
Adv Exp Med Biol
. 2016 May;
898:265-304.
PMID: 27161233
ThermoTRPs are unique channels that mediate Na(+) and Ca(2+) currents in response to changes in ambient temperature. In combination with their activation by other physical and chemical stimuli, they are...
10.
Devesa I, Ferrandiz-Huertas C, Mathivanan S, Wolf C, Lujan R, Changeux J, et al.
Proc Natl Acad Sci U S A
. 2014 Dec;
111(51):18345-50.
PMID: 25489075
Proalgesic sensitization of peripheral nociceptors in painful syndromes is a complex molecular process poorly understood that involves mobilization of thermosensory receptors to the neuronal surface. However, whether recruitment of vesicular...