Iris H Jonkers
Overview
Explore the profile of Iris H Jonkers including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
404
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0
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Recent Articles
1.
Bakker O, Claringbould A, Westra H, Wiersma H, Boulogne F, Vosa U, et al.
Sci Rep
. 2024 Dec;
14(1):30206.
PMID: 39632930
Genetic variants identified through genome-wide association studies (GWAS) are typically non-coding, exerting small regulatory effects on downstream genes. However, which downstream genes are ultimately impacted and how they confer risk...
2.
Simpson H, Smits E, Moerkens R, Wijmenga C, Mooiweer J, Jonkers I, et al.
Trends Mol Med
. 2024 Oct;
31(2):117-137.
PMID: 39448329
Coeliac disease (CeD) is an immune-mediated disorder characterised by gluten-triggered inflammation and damage in the small intestine, with lifelong gluten-free diet (GFD) as the only treatment. It is a multifactorial...
3.
Tan I, Modderman R, Stachurska A, Almeida R, de Vries R, Heersema D, et al.
Brain Commun
. 2024 Jul;
6(4):fcae209.
PMID: 38978729
Multiple sclerosis is a chronic demyelinating disease of the central nervous system. There is a need for new circulating biomarkers for multiple sclerosis, in particular, markers that differentiate multiple sclerosis...
4.
Moerkens R, Mooiweer J, Ramirez-Sanchez A, Oelen R, Franke L, Wijmenga C, et al.
Cell Rep
. 2024 Jun;
43(7):114247.
PMID: 38907996
Human induced pluripotent stem cell (hiPSC)-derived intestinal organoids are valuable tools for researching developmental biology and personalized therapies, but their closed topology and relative immature state limit applications. Here, we...
5.
Lincoln M, Connally N, Axisa P, Gasperi C, Mitrovic M, van Heel D, et al.
Nat Genet
. 2024 May;
56(5):838-845.
PMID: 38741015
Autoimmune and inflammatory diseases are polygenic disorders of the immune system. Many genomic loci harbor risk alleles for several diseases, but the limited resolution of genetic mapping prevents determining whether...
6.
Shaw D, Aguirre-Gamboa R, Vieira M, Gona S, Dinardi N, Wang A, et al.
Nat Med
. 2023 Jun;
29(6):1520-1529.
PMID: 37322120
Primary sclerosing cholangitis (PSC) is an immune-mediated disease of the bile ducts that co-occurs with inflammatory bowel disease (IBD) in almost 90% of cases. Colorectal cancer is a major complication...
7.
Palasantzas V, Tamargo-Rubio I, Le K, Slager J, Wijmenga C, Jonkers I, et al.
Trends Genet
. 2023 Feb;
39(4):268-284.
PMID: 36746737
Genome-wide association studies (GWAS) have now correlated hundreds of genetic variants with complex genetic diseases and drug efficacy. Functional characterization of these factors remains challenging, particularly because of the lack...
8.
Ramirez-Sanchez A, Chu X, Modderman R, Kooy-Winkelaar Y, Koletzko S, Korponay-Szabo I, et al.
Front Immunol
. 2022 Apr;
13:843086.
PMID: 35371081
Celiac Disease (CeD) is a complex immune disorder involving villous atrophy in the small intestine that is triggered by gluten intake. Current CeD diagnosis is based on late-stage pathophysiological parameters...
9.
Chu X, Jaeger M, Beumer J, Bakker O, Aguirre-Gamboa R, Oosting M, et al.
Genome Biol
. 2021 Jul;
22(1):198.
PMID: 34229738
Background: Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors. Result: We...
10.
Bakker O, Ramirez-Sanchez A, Borek Z, de Klein N, Li Y, Modderman R, et al.
Sci Rep
. 2021 Apr;
11(1):9252.
PMID: 33927210
Celiac disease is an auto-immune disease in which an immune response to dietary gluten leads to inflammation and subsequent atrophy of small intestinal villi, causing severe bowel discomfort and malabsorption...