Irina Y Tcherepanova
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Explore the profile of Irina Y Tcherepanova including associated specialties, affiliations and a list of published articles.
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15
Citations
435
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Recent Articles
1.
Moretti A, Ponzo M, Nicolette C, Tcherepanova I, Biondi A, Magnani C
Front Immunol
. 2022 Jun;
13:867013.
PMID: 35757746
Adoptive transfer of chimeric antigen receptor (CAR) T lymphocytes is a powerful technology that has revolutionized the way we conceive immunotherapy. The impressive clinical results of complete and prolonged response...
2.
Gay C, Kuruc J, Falcinelli S, Warren J, Reifeis S, Kirchherr J, et al.
Sci Rep
. 2020 Mar;
10(1):5134.
PMID: 32198428
Approaches to deplete persistent HIV infection are needed. We investigated the combined impact of the latency reversing agent vorinostat (VOR) and AGS-004, an autologous dendritic cell immunotherapeutic, on the HIV...
3.
Figlin R, Tannir N, Uzzo R, Tykodi S, Chen D, Master V, et al.
Clin Cancer Res
. 2020 Feb;
26(10):2327-2336.
PMID: 32034074
Purpose: Rocapuldencel-T is an autologous immunotherapy prepared from mature monocyte-derived dendritic cells (DC), coelectroporated with amplified tumor RNA plus CD40L RNA. This pivotal phase III trial was initiated to investigate...
4.
Gay C, DeBenedette M, Tcherepanova I, Gamble A, Lewis W, Cope A, et al.
AIDS Res Hum Retroviruses
. 2017 Jun;
34(1):111-122.
PMID: 28636433
AGS-004 consists of matured autologous dendritic cells co-electroporated with in vitro transcribed RNA encoding autologous HIV antigens. In an open-label, single arm sub-study of AGS-004-003, AGS-004 was administered monthly to...
5.
Horvatinovich J, Grogan E, Norris M, Steinkasserer A, Lemos H, Mellor A, et al.
J Immunol
. 2017 Feb;
198(6):2286-2301.
PMID: 28193829
The transmembrane protein CD83, expressed on APCs, B cells, and T cells, can be expressed as a soluble form generated by alternative splice variants and/or by shedding. Soluble CD83 (sCD83)...
6.
Amin A, Dudek A, Logan T, Lance R, Holzbeierlein J, Knox J, et al.
J Immunother Cancer
. 2015 Apr;
3:14.
PMID: 25901286
Background: AGS-003 is an autologous immunotherapy prepared from fully matured and optimized monocyte-derived dendritic cells, which are co-electroporated with amplified tumor RNA plus synthetic CD40L RNA. AGS-003 was evaluated in...
7.
Jenabian M, Nicolette C, Tcherepanova I, DeBenedette M, Gilmore N, Routy J
J Acquir Immune Defic Syndr
. 2013 Sep;
64(4):345-50.
PMID: 24025338
We previously reported that a combination of antiretroviral therapy with 4 monthly injections of each patient's own autologous dendritic cells (AGS-004) electroporated with CD40 ligand and with HIV RNA antigens...
8.
Bock F, Rossner S, Onderka J, Lechmann M, Pallotta M, Fallarino F, et al.
J Immunol
. 2013 Jul;
191(4):1965-75.
PMID: 23851696
Modulation of immune responses is one of the main research aims in transplant immunology. In this study, we investigate the local immunomodulatory properties of soluble CD83 (sCD83) at the graft-host...
9.
Slagter-Jager J, Raney A, Lewis W, DeBenedette M, Nicolette C, Tcherepanova I
Mol Ther Nucleic Acids
. 2013 May;
2:e91.
PMID: 23653155
Dendritic cells (DCs) transfected with total amplified tumor cell RNA have the potential to induce broad antitumor immune responses. However, analytical methods required for quantitatively assessing the integrity, fidelity, and...
10.
Slagter-Jager J, Nicolette C, Tcherepanova I
J Pharm Biomed Anal
. 2012 Jun;
70:657-63.
PMID: 22703839
Ribonucleic acid (RNA) is gaining utility as a key component of immunotherapeutics to transiently express antigens or to modulate endogenous gene expression for clinical applications. As a key ancillary component...