Irina Kusmartseva
Overview
Explore the profile of Irina Kusmartseva including associated specialties, affiliations and a list of published articles.
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35
Citations
896
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Recent Articles
1.
Melton R, Jimenez S, Elison W, Tucciarone L, Howell A, Wang G, et al.
bioRxiv
. 2025 Mar;
PMID: 40027657
Cell type-specific regulatory programs that drive type 1 diabetes (T1D) in the pancreas are poorly understood. Here we performed single nucleus multiomics and spatial transcriptomics in up to 32 non-diabetic...
2.
Huber M, Widener A, Cuaycal A, Smurlick D, Butterworth E, Lenchik N, et al.
bioRxiv
. 2025 Jan;
PMID: 39763971
The loss of insulin secretory function associated with type 1 diabetes (T1D) is attributed to the immune-mediated destruction of beta cells. Yet, at onset of T1D, patients often have a...
3.
Saunders D, Hart N, Pan F, Reihsmann C, Hopkirk A, Izmaylov N, et al.
bioRxiv
. 2025 Jan;
PMID: 39763926
Human endocrine cell differentiation and islet morphogenesis play critical roles in determining islet cell mass and function, but the events and timeline of these processes are incompletely defined. To better...
4.
Ward H, Anquetil F, Das V, Gibson C, Dovmark T, Kusmartseva I, et al.
Kidney360
. 2024 Nov;
PMID: 39499578
Background: The Network for Pancreatic Organ donors with Diabetes-Kidney (nPOD-K) project was initiated to assess the feasibility of using kidneys from organ donors to enhance understanding of diabetic kidney disease...
5.
Kusmartseva I, Posgai A, Yang M, Oram R, Atkinson M, Pugliese A, et al.
Cold Spring Harb Perspect Med
. 2024 Aug;
PMID: 39134385
The Network for Pancreatic Organ Donors with Diabetes (nPOD) has helped shape the contemporary understanding of type 1 diabetes (T1D) pathogenesis in humans through the procurement, distribution to scientists, and...
6.
Perry D, Shapiro M, Chamberlain S, Kusmartseva I, Chamala S, Balzano-Nogueira L, et al.
Sci Data
. 2023 May;
10(1):323.
PMID: 37237059
The Network for Pancreatic Organ donors with Diabetes (nPOD) is the largest biorepository of human pancreata and associated immune organs from donors with type 1 diabetes (T1D), maturity-onset diabetes of...
7.
Redondo M, Richardson S, Perry D, Minard C, Carr A, Brusko T, et al.
Diabetologia
. 2022 Oct;
66(1):127-131.
PMID: 36282337
Aims/hypothesis: TCF7L2 variants are the strongest genetic risk factor for type 2 diabetes. In individuals with type 1 diabetes, these variants are associated with a higher C-peptide AUC, a lower...
8.
Kulkarni S, Posgai A, Kusmartseva I, Wasserfall C, Atkinson M, Butler A
J Endocr Soc
. 2022 Oct;
6(11):bvac136.
PMID: 36249412
Context: We recently demonstrated increased cellular proliferation in the pancreatic ductal gland (PDG) compartment of organ donors with type 1 diabetes, suggesting that PDGs may harbor progenitor cells capable of...
9.
van der Heide V, Jangra S, Cohen P, Rathnasinghe R, Aslam S, Aydillo T, et al.
Cell Rep
. 2022 Mar;
38(11):110508.
PMID: 35247306
Concerns that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), may cause new-onset diabetes persist in an evolving research landscape, and...
10.
Wu M, Lee M, Bahl V, Traum D, Schug J, Kusmartseva I, et al.
Cell Rep
. 2021 Nov;
37(5):109919.
PMID: 34731614
Type 2 diabetes mellitus (T2D) is a chronic age-related disorder characterized by hyperglycemia due to the failure of pancreatic beta cells to compensate for increased insulin demand. Despite decades of...