Irfan M Hisamuddin
Overview
Explore the profile of Irfan M Hisamuddin including associated specialties, affiliations and a list of published articles.
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9
Citations
459
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Recent Articles
1.
Hisamuddin I, Yang V
Curr Colorectal Cancer Rep
. 2008 Dec;
2(2):53-59.
PMID: 19079560
Colorectal cancer (CRC) is a major cause of morbidity and mortality from cancers in the United States. Recent studies have revealed the paradigm in which sequential genetic changes (mutations) result...
2.
Hisamuddin I, Yang V
Pharmacogenomics
. 2007 Jun;
8(6):635-43.
PMID: 17559352
Flavin-containing monooxygenase 3 (FMO3) is a hepatic microsomal enzyme that oxidizes a host of drugs, xenobiotics and other chemicals. Numerous variants in the gene encoding FMO3 have been identified, some...
3.
Hisamuddin I, Wehbi M, Yang V
Curr Opin Gastroenterol
. 2006 Nov;
23(1):60-6.
PMID: 17133087
Purpose Of Review: The deciphering of the human genome sequence has enabled the identification of genetic polymorphisms that are responsible for inter-individual variation in the response to drug therapy. This...
4.
Hisamuddin I, Wehbi M, Schmotzer B, Easley K, Hylind L, Giardiello F, et al.
Cancer Epidemiol Biomarkers Prev
. 2005 Oct;
14(10):2366-9.
PMID: 16214918
Sulindac is a nonsteroidal antiinflammatory drug with a chemopreventive effect in patients with familial adenomatous polyposis (FAP). In vivo, the active form of sulindac is sulindac sulfide, which is inactivated...
5.
Yoon H, Ghaleb A, Nandan M, Hisamuddin I, Dalton W, Yang V
Oncogene
. 2005 Apr;
24(25):4017-25.
PMID: 15806166
Centrosome duplication is a carefully controlled process in the cell cycle. Previous studies indicate that the tumor suppressor, p53, regulates centrosome duplication. Here, we present evidence for the involvement of...
6.
Ghaleb A, Nandan M, Chanchevalap S, Dalton W, Hisamuddin I, Yang V
Cell Res
. 2005 Mar;
15(2):92-6.
PMID: 15740636
Krüppel-like factors (KLFs) are evolutionarily conserved zinc finger-containing transcription factors with diverse regulatory functions in cell growth, proliferation, differentiation, and embryogenesis. KLF4 and KLF5 are two closely related members of...
7.
Hisamuddin I, Wehbi M, Chao A, Wyre H, Hylind L, Giardiello F, et al.
Clin Cancer Res
. 2004 Dec;
10(24):8357-62.
PMID: 15623613
Purpose: Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) effective in regressing adenomas in patients with familial adenomatous polyposis (FAP). However, a recent randomized trial showed that sulindac, when compared with...
8.
Hisamuddin I, Yang V
MedGenMed
. 2004 Nov;
6(3):13.
PMID: 15520636
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in the United States. As such, it assumes a significant role in both health policy decision-making and scientific research....
9.
Zhao W, Hisamuddin I, Nandan M, Babbin B, Lamb N, Yang V
Oncogene
. 2004 Jan;
23(2):395-402.
PMID: 14724568
Krüppel-like factor 4 (KLF4 or GKLF) is an inhibitor of the cell cycle. The gene encoding KLF4 is localized on chromosome 9q, previously shown to exhibit allelic loss in colorectal...