Irene Lopez-Gonzalez
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Explore the profile of Irene Lopez-Gonzalez including associated specialties, affiliations and a list of published articles.
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22
Citations
598
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Recent Articles
11.
Lopez-Gonzalez I, Perez-Mediavilla A, Zamarbide M, Carmona M, Escribano B, Glatzel M, et al.
J Neuropathol Exp Neurol
. 2016 Jan;
75(2):121-33.
PMID: 26733586
Familial encephalopathy with neuroserpin inclusion bodies (FENIB) is a rare disease characterized by the deposition of multiple intracytoplasmic neuronal inclusions that contain mutated neuroserpin. Tg-Syracuse (Tg-Syr) mice express Ser49Pro mutated...
12.
Lopez-Gonzalez I, Aso E, Carmona M, Armand-Ugon M, Blanco R, Naudi A, et al.
J Neuropathol Exp Neurol
. 2015 Sep;
74(10):975-99.
PMID: 26360374
Tau P301S transgenic mice (PS19 line) are used as a model of frontotemporal lobar degeneration (FTLD)-tau. Behavioral alterations in these mice begin at approximately 4 months of age. We analyzed...
13.
Sola I, Aso E, Frattini D, Lopez-Gonzalez I, Espargaro A, Sabate R, et al.
J Med Chem
. 2015 Jul;
58(15):6018-32.
PMID: 26181606
We have synthesized a series of heptamethylene-linked levetiracetam-huprine and levetiracetam-(6-chloro)tacrine hybrids to hit amyloid, tau, and cholinergic pathologies as well as β-amyloid (Aβ)-induced epileptiform activity, some of the mechanisms that...
14.
Lopez-Gonzalez I, Schluter A, Aso E, Garcia-Esparcia P, Ansoleaga B, Llorens F, et al.
J Neuropathol Exp Neurol
. 2015 Mar;
74(4):319-44.
PMID: 25756590
To understand neuroinflammation-related gene regulation during normal aging and in sporadic Alzheimer disease (sAD), we performed functional genomics analysis and analyzed messenger RNA (mRNA) expression by quantitative reverse transcription-polymerase chain...
15.
Llorens F, Lopez-Gonzalez I, Thune K, Carmona M, Zafar S, Andreoletti O, et al.
Front Aging Neurosci
. 2014 Aug;
6:198.
PMID: 25136317
The present study identifies deregulated cytokines and mediators of the immune response in the frontal cortex and cerebellum of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 and VV2 subtypes compared to age-matched...
16.
Lopez-Gonzalez I, Carmona M, Arregui L, Kovacs G, Ferrer I
Neuropathology
. 2014 Jul;
34(6):517-26.
PMID: 24985029
Tauopathies are neurodegenerative diseases characterized by hyper-phosphorylated tau deposition in neurons and glial cells. Chaperones, such as small heat shock proteins αB-crystallin and HSP27 highly expressed in normal glial cells,...
17.
Ferrer I, Lopez-Gonzalez I, Carmona M, Arregui L, Dalfo E, Torrejon-Escribano B, et al.
J Neuropathol Exp Neurol
. 2013 Dec;
73(1):81-97.
PMID: 24335532
Tauopathies are degenerative diseases characterized by the accumulation of phosphorylated tau in neurons and glial cells. With some exceptions, tau deposits in neurons are mainly manifested as pretangles and tangles...
18.
Llorens F, Ansoleaga B, Garcia-Esparcia P, Zafar S, Grau-Rivera O, Lopez-Gonzalez I, et al.
Prion
. 2013 Sep;
7(5):383-93.
PMID: 24047819
Creutzfeldt-Jakob disease (CJD) is a heterogenic neurodegenerative disorder associated with abnormal post-translational processing of cellular prion protein (PrP(c)). CJD displays distinctive clinical and pathological features which correlate with the genotype...
19.
Adams A, Navarro-Lopez R, Ramirez-Aguilar F, Lopez-Gonzalez I, Leal G, Flores-Mayorga J, et al.
PLoS Negl Trop Dis
. 2012 Nov;
6(11):e1875.
PMID: 23133685
Venezuelan equine encephalitis virus (VEEV) has been the causative agent for sporadic epidemics and equine epizootics throughout the Americas since the 1930s. In 1969, an outbreak of Venezuelan equine encephalitis...
20.
Lopez-Gonzalez I, Carmona M, Blanco R, Luna-Munoz J, Martinez-Mandonado A, Mena R, et al.
Brain Pathol
. 2012 Aug;
23(2):144-53.
PMID: 22882361
Thorn-shaped astrocytes (TsA) are mainly localized in the periventricular white matter of the temporal lobe in a subgroup of aged individuals usually in the context of Alzheimer's disease (AD). Immunohistochemistry...