Irafasha C Casmil
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Explore the profile of Irafasha C Casmil including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Maine C, Miyake-Stoner S, Spasova D, Picarda G, Chou A, Brand E, et al.
Nat Commun
. 2025 Jan;
16(1):456.
PMID: 39774967
Self-replicating RNA (srRNA) technology, in comparison to mRNA vaccines, has shown dose-sparing by approximately 10-fold and more durable immune responses. However, no improvements are observed in the adverse events profile....
2.
Casmil I, Bathula N, Huang C, Wayne C, Cairns E, Friesen J, et al.
Mol Ther
. 2025 Jan;
33(2):514-528.
PMID: 39741413
Self-amplifying RNA (saRNA) vectors are a next-generation RNA technology that extends the expression of heterologous genes. Clinical trials have shown the dose-sparing capacity of saRNA vectors in a vaccine context...
3.
Liao S, Wang S, Wadhwa A, Birkenshaw A, Fox K, Cheng M, et al.
ACS Appl Mater Interfaces
. 2024 Dec;
17(2):3097-3105.
PMID: 39737597
When formulating mRNA into lipid nanoparticles (LNP), various copy numbers of mRNA are encapsulated, leading to a distribution of mRNA loading levels within the LNPs. It is unclear whether the...
4.
Bathula N, Friesen J, Casmil I, Wayne C, Liao S, Soriano S, et al.
J Control Release
. 2024 Aug;
374:28-38.
PMID: 39097193
Self-amplifying RNA (saRNA) is a next-generation RNA platform derived from an alphavirus that enables replication in host cytosol, offering a promising shift from traditional messenger RNA (mRNA) therapies by enabling...
5.
6.
Casmil I, Huang C, Blakney A
Sci Rep
. 2023 Nov;
13(1):19050.
PMID: 37923834
Self-amplifying messenger ribonucleic acid (saRNA) provides extended expression of genes of interest by encoding an alphavirus-derived RNA replicase and thus is 2-3 times larger than conventional messenger RNA. However, quality...