Inna V Krieger
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Explore the profile of Inna V Krieger including associated specialties, affiliations and a list of published articles.
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18
Citations
206
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Recent Articles
1.
Zhou N, Tang S, Bian X, Parai M, Krieger I, Flores A, et al.
Cell Rep
. 2024 Nov;
43(11):114929.
PMID: 39504242
Safe, effective, and low-cost oral antiviral therapies are needed to treat those at high risk for developing severe COVID-19. To that end, we performed a high-throughput screen to identify non-peptidic,...
2.
Qu D, Ge P, Botella L, Park S, Lee H, Thornton N, et al.
Nat Commun
. 2024 May;
15(1):4161.
PMID: 38755122
Lipid biosynthesis in the pathogen Mycobacterium tuberculosis depends on biotin for posttranslational modification of key enzymes. However, the mycobacterial biotin synthetic pathway is not fully understood. Here, we show that...
3.
Krieger I, Yalamanchili S, Dickson P, Engelhart C, Zimmerman M, Wood J, et al.
ACS Infect Dis
. 2024 Apr;
10(5):1561-1575.
PMID: 38577994
DNA-encoded chemical library (DEL) technology provides a time- and cost-efficient method to simultaneously screen billions of compounds for their affinity to a protein target of interest. Here we report its...
4.
Guo T, Sperber A, Krieger I, Duan Y, Chemelewski V, Sacchettini J, et al.
J Bacteriol
. 2023 Dec;
206(1):e0020223.
PMID: 38047707
YisK is an uncharacterized protein in previously shown to interact genetically with the elongasome protein Mbl. YisK overexpression leads to cell widening and lysis, phenotypes that are dependent on and...
5.
Singh V, Grzegorzewicz A, Fienberg S, Muller R, Khonde L, Sanz O, et al.
ACS Infect Dis
. 2022 Nov;
8(11):2315-2326.
PMID: 36325756
Alternative mode-of-inhibition of clinically validated targets is an effective strategy for circumventing existing clinical drug resistance. Herein, we report 1,3-diarylpyrazolyl-acylsulfonamides as potent inhibitors of HadAB/BC, a 3-hydroxyl-ACP dehydratase complex required...
6.
Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists
Katti S, Krieger I, Ann J, Lee J, Sacchettini J, Igumenova T
Nat Commun
. 2022 May;
13(1):2695.
PMID: 35577811
Diacylglycerol (DAG) is a versatile lipid whose 1,2-sn-stereoisomer serves both as second messenger in signal transduction pathways that control vital cellular processes, and as metabolic precursor for downstream signaling lipids...
7.
Kreutzfeldt K, Jansen R, Hartman T, Gouzy A, Wang R, Krieger I, et al.
Nat Commun
. 2022 Apr;
13(1):2203.
PMID: 35459278
The ability of Mycobacterium tuberculosis (Mtb) to resist and tolerate antibiotics complicates the development of improved tuberculosis (TB) chemotherapies. Here we define the Mtb protein CinA as a major determinant...
8.
Mellott D, Torres D, Krieger I, Cameron S, Moghadamchargari Z, Laganowsky A, et al.
J Am Chem Soc
. 2021 Oct;
143(42):17666-17676.
PMID: 34664502
The isocitrate lyase paralogs of (ICL1 and 2) are essential for mycobacterial persistence and constitute targets for the development of antituberculosis agents. We report that (2,3)-2-hydroxy-3-(nitromethyl)succinic acid (5-NIC) undergoes apparent...
9.
Krieger I, Kuznetsov V, Chang J, Zhang J, Moussa S, Young R, et al.
J Mol Biol
. 2020 Jun;
432(16):4623-4636.
PMID: 32562709
Optimal phage propagation depends on the regulation of the lysis of the infected host cell. In T4 phage infection, lysis occurs when the holin protein (T) forms lesions in the...
10.
Crutcher F, Moran-Diez M, Krieger I, Kenerley C
Fungal Genet Biol
. 2019 Jun;
131:103245.
PMID: 31228644
Trichoderma spp. have been characterized for their capacity to act as biological control agents against several pathogens through the activity of secondary metabolites and cell wall degrading enzymes. However, only...