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Ingel K Demedts

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Articles 18
Citations 1061
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Recent Articles
1.
Bosteels C, Van Damme K, De Leeuw E, Declercq J, Maes B, Bosteels V, et al.
Cell Rep Med . 2022 Dec; 3(12):100833. PMID: 36459994
GM-CSF promotes myelopoiesis and inflammation, and GM-CSF blockade is being evaluated as a treatment for COVID-19-associated hyperinflammation. Alveolar GM-CSF is, however, required for monocytes to differentiate into alveolar macrophages (AMs)...
2.
De Leeuw E, Van Damme K, Declercq J, Bosteels C, Maes B, Tavernier S, et al.
Respir Res . 2022 Aug; 23(1):202. PMID: 35945604
Background: The efficacy and safety of complement inhibition in COVID-19 patients is unclear. Methods: A multicenter randomized controlled, open-label trial. Hospitalized COVID-19 patients with signs of systemic inflammation and hypoxemia...
3.
Declercq J, Van Damme K, De Leeuw E, Maes B, Bosteels C, Tavernier S, et al.
Lancet Respir Med . 2021 Nov; 9(12):1427-1438. PMID: 34756178
Background: Infections with SARS-CoV-2 continue to cause significant morbidity and mortality. Interleukin (IL)-1 and IL-6 blockade have been proposed as therapeutic strategies in COVID-19, but study outcomes have been conflicting....
4.
Vermeersch K, Belmans A, Bogaerts K, Gyselinck I, Cardinaels N, Gabrovska M, et al.
Respir Res . 2019 Oct; 20(1):237. PMID: 31665017
Background: In the BACE trial, a 3-month (3 m) intervention with azithromycin, initiated at the onset of an infectious COPD exacerbation requiring hospitalization, decreased the rate of a first treatment...
5.
Vermeersch K, Gabrovska M, Aumann J, Demedts I, Corhay J, Marchand E, et al.
Am J Respir Crit Care Med . 2019 May; 200(7):857-868. PMID: 31046405
Azithromycin prevents acute exacerbations of chronic obstructive pulmonary disease (AECOPDs); however, its value in the treatment of an AECOPD requiring hospitalization remains to be defined. We investigated whether a 3-month...
6.
Vermeersch K, Gabrovska M, Deslypere G, Demedts I, Slabbynck H, Aumann J, et al.
Int J Chron Obstruct Pulmon Dis . 2016 Apr; 11:687-96. PMID: 27099485
Background: Long-term use of macrolide antibiotics is effective to prevent exacerbations in chronic obstructive pulmonary disease (COPD). As risks and side effects of long-term intervention outweigh the benefits in the...
7.
Brusselle G, Vanderstichele C, Jordens P, Deman R, Slabbynck H, Ringoet V, et al.
Thorax . 2013 Jan; 68(4):322-9. PMID: 23291349
Background: Patients with severe asthma are at increased risk of exacerbations and lower respiratory tract infections (LRTI). Severe asthma is heterogeneous, encompassing eosinophilic and non-eosinophilic (mainly neutrophilic) phenotypes. Patients with...
8.
van Pottelberge G, Bracke K, Demedts I, De Rijck K, Reinartz S, Van Drunen C, et al.
Respir Res . 2010 Mar; 11:35. PMID: 20307269
Background: Dendritic cells (DC) linking innate and adaptive immune responses are present in human lungs, but the characterization of different subsets and their role in COPD pathogenesis remain to be...
9.
Tsoumakidou M, Demedts I, Brusselle G, Jeffery P
Am J Respir Crit Care Med . 2008 Mar; 177(11):1180-6. PMID: 18337593
Dendritic cells (DCs) are professional antigen-presenting cells responsible for immune homeostasis. In the lung's responses to tissue damage or infection, they initiate and orchestrate innate and adaptive immunity. There are...
10.
Bracke K, Demedts I, Joos G, Brusselle G
Inflamm Allergy Drug Targets . 2007 Aug; 6(2):75-9. PMID: 17692030
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality and disability in the world, with a prevalence that is expected to increase in the next decades....